PMID- 25721484
OWN - NLM
STAT- MEDLINE
DCOM- 20150904
LR  - 20210913
IS  - 1421-9883 (Electronic)
IS  - 0253-4886 (Linking)
VI  - 32
IP  - 1
DP  - 2015
TI  - Gallbladder ejection fraction declines with age in patients undergoing 
      cholecystectomy for acalculous biliary symptoms but has low accuracy in the 
      prediction of gallbladder pathology.
PG  - 68-72
LID - 10.1159/000371455 [doi]
AB  - BACKGROUND/AIMS: Hepatobiliary Iminodiacetic Acid (HIDA) scan provides a 
      technique to quantify gallbladder ejection fraction (EF) in patients suffering 
      acalculous biliary colic (ACBC). We wished to evaluate the accuracy of EF in the 
      prediction of gallbladder pathology in patients undergoing cholecystectomy. 
      METHODS: Data were retrieved from a database of patients referred for HIDA scan 
      for ACBC, including EF and the pathological outcome of those undergoing 
      cholecystectomy, and compared to normal values obtained from a review of related 
      studies. Significant associations were demonstrated by chi-square, Mann-Whitney 
      test, and linear regression. The predictive accuracy of different cut-offs of EF 
      was demonstrated by the ROC curve analysis. RESULTS: Of 83 patients referred for 
      HIDA scan for ACBC, 41 underwent cholecystectomy. The median EF of this group 
      (33%) was significantly lower than the composite normal median value from 
      previous studies (56%). Thirty-two patients revealed evidence of gallbladder 
      pathology. The EF declined with age (coefficient = -0.51, 95% CI = -0.99 to 
      -0.33), but the median value did not differ between those with gallbladder 
      pathology (34%) and those with normal gallbladders (29%). CONCLUSION/DISCUSSION: 
      Although an EF cut-off of 35% had the greatest accuracy in the prediction of 
      pathology of those tested (0.56), the poor negative predictive value (23.5%) was 
      a major contributor to its low accuracy. Although patients with ACBC have reduced 
      gallbladder EF compared to the normal population, its quantitative assessment is 
      of limited value in the prediction of gallbladder pathology.
FAU - Jones, Aled
AU  - Jones A
FAU - Shahtahmassebi, Golnaz
AU  - Shahtahmassebi G
FAU - Stell, David
AU  - Stell D
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Dig Surg
JT  - Digestive surgery
JID - 8501808
RN  - 0 (Radiopharmaceuticals)
RN  - 6433TZJ6TQ (Technetium Tc 99m Lidofenin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biliary Dyskinesia/*diagnostic imaging/physiopathology/surgery
MH  - Cholecystectomy, Laparoscopic
MH  - Female
MH  - Gallbladder/*diagnostic imaging/physiopathology/surgery
MH  - Gallbladder Diseases/*diagnostic imaging/physiopathology/surgery
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
MH  - Retrospective Studies
MH  - Technetium Tc 99m Lidofenin
EDAT- 2015/02/28 06:00
MHDA- 2015/09/05 06:00
CRDT- 2015/02/28 06:00
PHST- 2014/07/07 00:00 [received]
PHST- 2014/10/19 00:00 [accepted]
PHST- 2015/02/28 06:00 [entrez]
PHST- 2015/02/28 06:00 [pubmed]
PHST- 2015/09/05 06:00 [medline]
AID - 000371455 [pii]
AID - 10.1159/000371455 [doi]
PST - ppublish
SO  - Dig Surg. 2015;32(1):68-72. doi: 10.1159/000371455.