PMID- 2572177
OWN - NLM
STAT- MEDLINE
DCOM- 19891117
LR  - 20181217
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 257
IP  - 4 Pt 2
DP  - 1989 Oct
TI  - Central interleukin 1-elicited hyperinsulinemia is mediated by prostaglandins but 
      not autonomics.
PG  - R839-46
AB  - This laboratory previously reported that centrally administered interleukin 1 
      (IL-1) in fasted pentobarbital-anesthetized rats elicited significant 
      hyperinsulinemic and febrile responses. In characterizing this putative central 
      mechanism for the regulation of pancreatic insulin secretion, hyperinsulinemia 
      and fever elicited by IL-1 injected intravenously (iv) or 
      intracerebroventricularly (icv) was totally eliminated by prior cyclooxygenase 
      inhibition with indomethacin, ibuprofen, or meclofenamate but not lipoxygenase 
      inhibition with propyl gallate or leukotriene receptor antagonism with LY 171883. 
      Furthermore, central administration of prostaglandin E2 at 10 and 100 ng doses 
      consistently evoked hyperinsulinemic, hypercorticotropinemic, and febrile 
      responses in anesthetized rats maintained on isothermal pads. beta-Adrenergic and 
      vagus nerves to the pancreatic beta-cells seemed likely candidates to mediate the 
      enhanced secretion of insulin elicited by IL-1 acting centrally. However, 
      pretreatment of rats with hexamethonium, propanolol, atropine, or bilateral 
      subdiaphragmatic vagotomy all failed to reduce hyperinsulinemia after IL-1 iv or 
      icv. This evidence suggests that the central mechanism for enhanced pancreatic 
      insulin secretion elicited by IL-1 may depend on a humoral rather than autonomic 
      neural efferent pathway. Moreover, the hyperinsulinemia is mediated in part by 
      prostaglandins just like the well-studied febrile response.
FAU - Cornell, R P
AU  - Cornell RP
AD  - Division of Science, Northeast Missouri State University, Kirksville 63501.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Acetophenones)
RN  - 0 (Hexamethonium Compounds)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-1)
RN  - 0 (SRS-A)
RN  - 0 (Tetrazoles)
RN  - 3C9PSP36Z2 (Hexamethonium)
RN  - 48I5LU4ZWD (Meclofenamic Acid)
RN  - 7C0697DR9I (Atropine)
RN  - 88107-10-2 (LY 171883)
RN  - 8D4SNN7V92 (Propyl Gallate)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9007-92-5 (Glucagon)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - K7Q1JQR04M (Dinoprostone)
RN  - WK2XYI10QM (Ibuprofen)
RN  - XXE1CET956 (Indomethacin)
RN  - Z468598HBV (Phentolamine)
SB  - IM
MH  - Acetophenones/pharmacology
MH  - Adrenocorticotropic Hormone/blood/metabolism
MH  - Animals
MH  - Atropine/pharmacology
MH  - Autonomic Nervous System/drug effects/*physiology
MH  - Body Temperature/*drug effects
MH  - Cerebral Ventricles/drug effects/*physiology
MH  - Dinoprostone/*pharmacology
MH  - Glucagon/blood/metabolism
MH  - Hexamethonium
MH  - Hexamethonium Compounds/pharmacology
MH  - Hyperinsulinism/*chemically induced
MH  - Ibuprofen/pharmacology
MH  - Indomethacin/pharmacology
MH  - Injections, Intraventricular
MH  - Insulin/blood/*metabolism
MH  - Insulin Secretion
MH  - Interleukin-1/administration & dosage/*pharmacology
MH  - Male
MH  - Meclofenamic Acid/pharmacology
MH  - Phentolamine/pharmacology
MH  - Propranolol/pharmacology
MH  - Propyl Gallate/pharmacology
MH  - Rats
MH  - Reference Values
MH  - SRS-A/antagonists & inhibitors
MH  - Tetrazoles/pharmacology
MH  - Vagotomy
EDAT- 1989/10/01 00:00
MHDA- 1989/10/01 00:01
CRDT- 1989/10/01 00:00
PHST- 1989/10/01 00:00 [pubmed]
PHST- 1989/10/01 00:01 [medline]
PHST- 1989/10/01 00:00 [entrez]
AID - 10.1152/ajpregu.1989.257.4.R839 [doi]
PST - ppublish
SO  - Am J Physiol. 1989 Oct;257(4 Pt 2):R839-46. doi: 10.1152/ajpregu.1989.257.4.R839.