PMID- 2572183
OWN - NLM
STAT- MEDLINE
DCOM- 19891106
LR  - 20190903
IS  - 0340-2061 (Print)
IS  - 0340-2061 (Linking)
VI  - 180
IP  - 2
DP  - 1989
TI  - Placental toxicity in rats after administration of synthetic glucocorticoids. A 
      morphological, histochemical and immunohistochemical investigation.
PG  - 121-30
AB  - Administration of the synthetic glucocorticoids dexamethasone and triamcinolone 
      to pregnant rats between gestational day (GD) 16 and 20 caused dose-dependent 
      placental lesions on GD 21 and 22 which were detected by morphological, 
      histochemical and immunohistochemical means. Maternal blood spaces, trophoblast 
      layer and fetal blood vessels were altered primarily in the centre of the 
      placental labyrinth. Less severe changes were found in the junctional zone, 
      chorionic plate and intraplacental yolk sac. On GD 21, low doses increased the 
      amount of glycogen, while high doses induced a loss of glycogen. gamma-glutamyl 
      transpeptidase activity was increased in the spongiotrophoblast and the 
      labyrinthic trophoblast and dipeptidyl peptidase IV activity in fetal capillary 
      endothelium, whereas alpha-glutamyl aminopeptidase and microsomal alanyl 
      amino-peptidase were not affected. Additionally, in the fetal capillary 
      endothelium an increase of immunoreactivity for the von Willebrand factor 
      occurred. These data suggest that synthetic glucocorticoids affect placental 
      tissues at different and rather specific levels, which may in turn disturb 
      placental function and contribute to fetal maldevelopment.
FAU - Graf, R
AU  - Graf R
AD  - Department of Anatomy, Free University of Berlin, Federal Republic of Germany.
FAU - Gossrau, R
AU  - Gossrau R
FAU - Frank, H G
AU  - Frank HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Anat Embryol (Berl)
JT  - Anatomy and embryology
JID - 7505194
RN  - 0 (Glucocorticoids)
RN  - 0 (von Willebrand Factor)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 2.3.2.2 (gamma-Glutamyltransferase)
RN  - EC 3.4.14.- (Dipeptidyl-Peptidases and Tripeptidyl-Peptidases)
RN  - F446C597KA (Triamcinolone Acetonide)
SB  - IM
MH  - Animals
MH  - Dexamethasone/toxicity
MH  - Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Gestational Age
MH  - Glucocorticoids/*toxicity
MH  - Immunohistochemistry
MH  - Placenta/*drug effects/enzymology/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Triamcinolone Acetonide/toxicity
MH  - gamma-Glutamyltransferase/pharmacology
MH  - von Willebrand Factor/immunology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF00309763 [doi]
PST - ppublish
SO  - Anat Embryol (Berl). 1989;180(2):121-30. doi: 10.1007/BF00309763.