PMID- 2572244
OWN - NLM
STAT- MEDLINE
DCOM- 19891220
LR  - 20191101
VI  - 78
IP  - 3
DP  - 1989
TI  - Excitatory sulphur amino acid-evoked neurotransmitter release from rat brain 
      synaptosome fractions.
PG  - 195-208
AB  - The neuroactive sulphur-containing amino acids L-cysteate (CA), L-cysteine 
      sulphinate (CSA), L-homocysteine sulphinate (HSA), S-sulpho-L-cysteine (SC) and 
      L-homocysteate (HCA) evoked the release of previously accumulated D-[3H]aspartate 
      from rat brain cerebrocortical and cerebellar synaptosome fractions in a manner 
      that was wholly Ca2+-independent. However, analysis of endogenous release by hplc 
      revealed the presence of both Ca2+-dependent and -independent component of 
      L-glutamate release but only a Ca2+-independent component of L-aspartate release. 
      CA, CSA, HSA and SC but not HCA evoked the release of previously accumulated 
      [3H]GABA from synaptosome fractions by a mechanism shown to comprise both a 
      Ca2+-dependent and -independent component. The specific antagonists of the 
      N-methyl-D-aspartate (NMDA) receptor, 
      3-[(+/-)-2-carboxypiperazin-4-yl]propyl-l-phosphonic acid (CPP) and the 
      relatively selective competitive quisqualate (QUIS)/kainate (KA) receptor 
      antagonist, 6-cyano-7-dinitroquinoxalinedione (CNQX), were ineffective in 
      blocking the excitatory sulphur amino acid-evoked release of either 
      D-[3H]aspartate, [3H]GABA or of endogenous established transmitter amino acids.
FAU - Dunlop, J
AU  - Dunlop J
AD  - Department of Biochemistry and Microbiology, University of St. Andrews, Scotland, 
      U.K.
FAU - Mason, H
AU  - Mason H
FAU - Grieve, A
AU  - Grieve A
FAU - Griffiths, R
AU  - Griffiths R
LA  - eng
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Austria
TA  - J Neural Transm Gen Sect
JT  - Journal of neural transmission. General section
JID - 9002201
RN  - 0 (Amino Acids)
RN  - 0 (Amino Acids, Sulfur)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Amino Acid)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Amino Acids/*metabolism/physiology
MH  - Amino Acids, Sulfur/*pharmacology
MH  - Animals
MH  - Brain/drug effects/*metabolism
MH  - Male
MH  - Neurotransmitter Agents/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Amino Acid
MH  - Receptors, Cell Surface/*metabolism
MH  - Synaptosomes/drug effects/*metabolism
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1007/BF01249229 [doi]
PST - ppublish
SO  - J Neural Transm Gen Sect. 1989;78(3):195-208. doi: 10.1007/BF01249229.