PMID- 25722682
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150227
LR  - 20201001
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 7
IP  - 12
DP  - 2012 Apr 25
TI  - 3,4-methylenedioxyamphetamine upregulates p75 neurotrophin receptor protein 
      expression in the rat brain.
PG  - 955-9
LID - 10.3969/j.issn.1673-5374.2012.12.013 [doi]
AB  - The p75 neurotrophin receptor, which is a member of the tumor necrosis factor 
      receptor superfamily, facilitates apoptosis during development and following 
      central nervous system injury. Previous studies have shown that programmed cell 
      death is likely involved in the neurotoxic effects of 3, 
      4-methylenedioxy-N-methylamphetamine (MDMA), because MDMA induces apoptosis of 
      immortalized neurons through regulation of proteins belonging to the Bcl-2 
      family. In the present study, intraperitoneal injection of different doses of 
      MDMA (20, 50, and 100 mg/kg) induced significant behavioral changes, such as 
      increased excitability, increased activity, and irritability in rats. Moreover, 
      changes exhibited dose-dependent adaptation. Following MDMA injection in rat 
      brain tissue, the number of apoptotic cells dose-dependently increased and p75 
      neurotrophin receptor expression significantly increased in the prefrontal 
      cortex, cerebellum, and hippocampus. These findings confirmed that MDMA induced 
      neuronal apoptosis, and results suggested that this effect was related by 
      upregulated protein expression of the p75 neurotrophin receptor.
FAU - Wang, Chaomin
AU  - Wang C
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
FAU - Peng, Zugui
AU  - Peng Z
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
FAU - Kuang, Weihong
AU  - Kuang W
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
FAU - Zheng, Hanyu
AU  - Zheng H
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
FAU - Long, Jiang
AU  - Long J
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
FAU - Wang, Xue
AU  - Wang X
AD  - Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, 
      Sichuan Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC4341294
OTO - NOTNLM
OT  - 3, 4-methylenedioxyamphetamine
OT  - apoptosis
OT  - cytotoxicity
OT  - neural regeneration
OT  - p75 neurotrophin receptor
COIS- Conflicts of interest: None declared.
EDAT- 2012/04/25 00:00
MHDA- 2012/04/25 00:01
PMCR- 2012/04/25
CRDT- 2015/02/28 06:00
PHST- 2011/11/01 00:00 [received]
PHST- 2012/02/24 00:00 [accepted]
PHST- 2015/02/28 06:00 [entrez]
PHST- 2012/04/25 00:00 [pubmed]
PHST- 2012/04/25 00:01 [medline]
PHST- 2012/04/25 00:00 [pmc-release]
AID - NRR-7-955 [pii]
AID - 10.3969/j.issn.1673-5374.2012.12.013 [doi]
PST - ppublish
SO  - Neural Regen Res. 2012 Apr 25;7(12):955-9. doi: 
      10.3969/j.issn.1673-5374.2012.12.013.