PMID- 25723617
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20211122
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 75
IP  - 3
DP  - 2015 May
TI  - Serum prostate-specific antigen levels in men with prediabetes: a cross-sectional 
      study.
PG  - 273-81
LID - 10.3109/00365513.2015.1010176 [doi]
AB  - BACKGROUND: Previous studies demonstrated that men with type 2 diabetes mellitus 
      (T2DM) had significantly lower serum prostate-specific antigen (PSA) levels than 
      healthy men. However, the influence of prediabetes (preDM) on serum PSA levels is 
      unknown. The aim of this study was to investigate the relationships between preDM 
      and serum PSA levels. METHODS: A cross-sectional analysis was conducted to 
      determine the relationships between preDM and serum PSA levels. Data were 
      obtained from men over 50 years of age who measured serum PSA levels in the 
      physical examination center of Tianjin Union Medical Center from May to July 
      2014. Pearson's correlation analysis and multivariable linear regression analysis 
      were utilized to calculate the correlations between PSA levels and various 
      clinical and biochemical variables. RESULTS: In age-matched analysis, the mean 
      PSA values were significantly higher in the preDM group compared with the 
      normoglycemia (NG) and T2DM groups (1.429 ng/mL vs. 1.086 ng/mL and 1.071 ng/mL; 
      p < 0.05). In addition, multivariable linear regression analysis demonstrated 
      that PSA was positively correlated with age, total cholesterol (TC) and preDM (p 
      < 0.05). Negative correlation existed between PSA and T2DM (p < 0.05). Men with 
      preDM had PSA values 31.6% higher than men without the condition (p < 0.05), 
      whereas PSA levels were 17.5% lower in men with T2DM than in those without the 
      condition (p < 0.05). CONCLUSIONS: Our results suggest preDM was an independent 
      determinant of high PSA levels and support that men with T2DM had decreased PSA 
      levels. Further larger studies are needed.
FAU - Sun, Ao
AU  - Sun A
AD  - Department of Clinical Laboratory, Tianjin Junliangcheng Hospital , Tianjin.
FAU - Liu, Rui
AU  - Liu R
FAU - Sun, Guangshan
AU  - Sun G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150227
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (Biomarkers)
RN  - EC 3.4.21.- (KLK3 protein, human)
RN  - EC 3.4.21.- (Kallikreins)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Humans
MH  - Kallikreins/*blood
MH  - Male
MH  - Middle Aged
MH  - Prediabetic State/*blood
MH  - Prostate-Specific Antigen/*blood
OTO - NOTNLM
OT  - Prostate-specific antigen
OT  - cross-sectional study
OT  - metabolic syndrome
OT  - prediabetes
OT  - type 2 diabetes mellitus
EDAT- 2015/02/28 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/02/28 06:00
PHST- 2015/02/28 06:00 [entrez]
PHST- 2015/02/28 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.3109/00365513.2015.1010176 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2015 May;75(3):273-81. doi: 
      10.3109/00365513.2015.1010176. Epub 2015 Feb 27.