PMID- 25724412
OWN - NLM
STAT- MEDLINE
DCOM- 20160408
LR  - 20240109
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 120
DP  - 2015 Apr
TI  - Chronic BDNF deficiency leads to an age-dependent impairment in spatial learning.
PG  - 52-60
LID - S1074-7427(15)00033-7 [pii]
LID - 10.1016/j.nlm.2015.02.009 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a crucial mediator of neural 
      plasticity and, consequently, of memory formation. In hippocampus-dependent 
      learning tasks BDNF also seems to play an essential role. However, there are 
      conflicting results concerning the spatial learning ability of aging BDNF(+/-) 
      mice in the Morris water maze paradigm. To evaluate the effect of chronic BDNF 
      deficiency in the hippocampus on spatial learning throughout life, we conducted a 
      comprehensive study to test differently aged BDNF(+/-) mice and their wild type 
      littermates in the Morris water maze and to subsequently quantify their 
      hippocampal BDNF protein levels as well as expression levels of TrkB receptors. 
      We observed an age-dependent learning deficit in BDNF(+/-) animals, starting at 
      seven months of age, despite stable hippocampal BDNF protein expression and 
      continual decline of TrkB receptor expression throughout aging. Furthermore, we 
      detected a positive correlation between hippocampal BDNF protein levels and 
      learning performance during the probe trial in animals that showed a good 
      learning performance during the long-term memory test.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Petzold, Anne
AU  - Petzold A
AD  - Institute for Physiology, Medical Faculty, Otto-von-Guericke University, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Psotta, Laura
AU  - Psotta L
AD  - Institute for Physiology, Medical Faculty, Otto-von-Guericke University, 
      Leipziger Str. 44, 39120 Magdeburg, Germany.
FAU - Brigadski, Tanja
AU  - Brigadski T
AD  - Institute for Physiology, Medical Faculty, Otto-von-Guericke University, 
      Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain 
      Sciences, Magdeburg, Germany.
FAU - Endres, Thomas
AU  - Endres T
AD  - Institute for Physiology, Medical Faculty, Otto-von-Guericke University, 
      Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: 
      thomas.endres@med.ovgu.de.
FAU - Lessmann, Volkmar
AU  - Lessmann V
AD  - Institute for Physiology, Medical Faculty, Otto-von-Guericke University, 
      Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain 
      Sciences, Magdeburg, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150224
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Blotting, Western
MH  - Brain-Derived Neurotrophic Factor/analysis/*deficiency/physiology
MH  - Hippocampus/chemistry
MH  - Male
MH  - Maze Learning/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
OTO - NOTNLM
OT  - Aging
OT  - Brain-derived neurotrophic factor
OT  - Hippocampus
OT  - Spatial learning
OT  - TrkB receptor
EDAT- 2015/03/01 06:00
MHDA- 2016/04/09 06:00
CRDT- 2015/03/01 06:00
PHST- 2014/08/18 00:00 [received]
PHST- 2015/02/07 00:00 [revised]
PHST- 2015/02/17 00:00 [accepted]
PHST- 2015/03/01 06:00 [entrez]
PHST- 2015/03/01 06:00 [pubmed]
PHST- 2016/04/09 06:00 [medline]
AID - S1074-7427(15)00033-7 [pii]
AID - 10.1016/j.nlm.2015.02.009 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2015 Apr;120:52-60. doi: 10.1016/j.nlm.2015.02.009. Epub 
      2015 Feb 24.