PMID- 25724495
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20200930
IS  - 1522-1539 (Electronic)
IS  - 0363-6135 (Linking)
VI  - 308
IP  - 9
DP  - 2015 May 1
TI  - Exercise excess pressure and exercise-induced albuminuria in patients with type 2 
      diabetes mellitus.
PG  - H1136-42
LID - 10.1152/ajpheart.00739.2014 [doi]
AB  - Exercise-induced albuminuria is common in patients with type 2 diabetes mellitus 
      (T2DM) in response to maximal exercise, but the response to light-moderate 
      exercise is unclear. Patients with T2DM have abnormal central hemodynamics and 
      greater propensity for exercise hypertension. This study sought to determine the 
      relationship between light-moderate exercise central hemodynamics (including 
      aortic reservoir and excess pressure) and exercise-induced albuminuria. 
      Thirty-nine T2DM (62 +/- 9 yr; 49% male) and 39 nondiabetic controls (53 +/- 9 yr; 
      51% male) were examined at rest and during 20 min of light-moderate cycle 
      exercise (30 W; 50 revolutions/min). Albuminuria was assessed by the 
      albumin-creatinine ratio (ACR) at rest and 30 min postexercise. Hemodynamics 
      recorded included brachial and central blood pressure (BP), aortic stiffness, 
      augmented pressure (AP), aortic reservoir pressure, and excess pressure integral 
      (Pexcess). There was no difference in ACR between groups before exercise (P > 
      0.05). Exercise induced a significant rise in ACR in T2DM but not controls (1.73 
      +/- 1.43 vs. 0.53 +/- 1.0 mg/mol, P = 0.002). All central hemodynamic variables were 
      significantly higher during exercise in T2DM (i.e., Pexcess, systolic BP and AP; 
      P < 0.01 all). In T2DM (but not controls), exercise Pexcess was associated with 
      postexercise ACR (r = 0.51, P = 0.002), and this relationship was independent of 
      age, sex, body mass index, heart rate, aortic stiffness, antihypertensive 
      medication, and ambulatory daytime systolic BP (beta = 0.003, P = 0.003). 
      Light-moderate exercise induced a significant rise in ACR in T2DM, and this was 
      independently associated with Pexcess, a potential marker of vascular 
      dysfunction. These novel findings suggest that Pexcess could be important for 
      appropriate renal function in T2DM.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Climie, Rachel E D
AU  - Climie RE
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia;
FAU - Srikanth, Velandai
AU  - Srikanth V
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia; 
      Stroke and Ageing Research Group, Monash Medical Centre, Department of Medicine, 
      Southern Clinical School, Monash University, Melbourne, Australia; and.
FAU - Keith, Laura J
AU  - Keith LJ
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia;
FAU - Davies, Justin E
AU  - Davies JE
AD  - International Centre for Circulatory Health, Imperial College, London, United 
      Kingdom.
FAU - Sharman, James E
AU  - Sharman JE
AD  - Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia; 
      James.Sharman@menzies.utas.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150227
PL  - United States
TA  - Am J Physiol Heart Circ Physiol
JT  - American journal of physiology. Heart and circulatory physiology
JID - 100901228
SB  - IM
MH  - Adult
MH  - Albuminuria/diagnosis/*etiology/physiopathology/urine
MH  - Bicycling
MH  - *Blood Pressure
MH  - Diabetes Mellitus, Type 2/*complications/diagnosis/physiopathology/urine
MH  - Diabetic Nephropathies/diagnosis/*etiology/physiopathology/urine
MH  - *Exercise
MH  - Female
MH  - Humans
MH  - Hypertension/diagnosis/*etiology/physiopathology
MH  - Kidney/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Risk Factors
MH  - Time Factors
MH  - Vascular Stiffness
OTO - NOTNLM
OT  - exercise blood pressure
OT  - physiology
OT  - renal dysfunction
EDAT- 2015/03/01 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/03/01 06:00
PHST- 2014/10/15 00:00 [received]
PHST- 2015/02/18 00:00 [accepted]
PHST- 2015/03/01 06:00 [entrez]
PHST- 2015/03/01 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - ajpheart.00739.2014 [pii]
AID - 10.1152/ajpheart.00739.2014 [doi]
PST - ppublish
SO  - Am J Physiol Heart Circ Physiol. 2015 May 1;308(9):H1136-42. doi: 
      10.1152/ajpheart.00739.2014. Epub 2015 Feb 27.