PMID- 25725300
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20150403
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 138
DP  - 2015 Apr
TI  - Hydroxylated polychlorinated biphenyls decrease circulating steroids in female 
      polar bears (Ursus maritimus).
PG  - 191-201
LID - S0013-9351(15)00039-0 [pii]
LID - 10.1016/j.envres.2015.02.011 [doi]
AB  - As a top predator in the Arctic food chain, polar bears (Ursus maritimus) are 
      exposed to high levels of persistent organic pollutants (POPs). Because several 
      of these compounds have been reported to alter endocrine pathways, such as the 
      steroidogenesis, potential disruption of the sex steroid synthesis by POPs may 
      cause implications for reproduction by interfering with ovulation, implantation 
      and fertility. Blood samples were collected from 15 female polar bears in 
      Svalbard (Norway) in April 2008. The concentrations of nine circulating steroid 
      hormones; dehydroepiandrosterone (DHEA), androstenedione (AN), testosterone (TS), 
      dihydrotestosterone (DHT), estrone (E1), 17alpha-estradiol (alphaE2), 17beta-estradiol 
      (betaE2), pregnenolone (PRE) and progesterone (PRO) were determined. The aim of the 
      study was to investigate associations among circulating levels of specific POP 
      compounds and POP-metabolites (hydroxylated PCBs [OH-PCBs] and hydroxylated PBDEs 
      [OH-PBDEs]), steroid hormones, biological and capture variables in female polar 
      bears. Inverse correlations were found between circulating levels of PRE and AN, 
      and circulating levels of OH-PCBs. There were no significant relationships 
      between the steroid concentrations and other analyzed POPs or the variables 
      capture date and capture location (latitude and longitude), lipid content, 
      condition and body mass. Although statistical associations do not necessarily 
      represent direct cause-effect relationships, the present study indicate that 
      OH-PCBs may affect the circulating levels of AN and PRE in female polar bears and 
      that OH-PCBs thus may interfere with the steroid homeostasis. Increase in PRO and 
      a decrease in AN concentrations suggest that the enzyme CYP17 may be a potential 
      target for OH-PCBs. In combination with natural stressors, ongoing climate change 
      and contaminant exposure, it is possible that OH-PCBs may disturb the 
      reproductive potential of polar bears.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gustavson, Lisa
AU  - Gustavson L
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
FAU - Ciesielski, Tomasz M
AU  - Ciesielski TM
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway. Electronic address: 
      tomasz.ciesielski@bio.ntnu.no.
FAU - Bytingsvik, Jenny
AU  - Bytingsvik J
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
FAU - Styrishave, Bjarne
AU  - Styrishave B
AD  - University of Copenhagen, Toxicology Laboratory, Department of Pharmacy, Faculty 
      of Health and Medical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark.
FAU - Hansen, Martin
AU  - Hansen M
AD  - University of Copenhagen, Toxicology Laboratory, Department of Pharmacy, Faculty 
      of Health and Medical Sciences, Universitetsparken 2, 2100 Copenhagen, Denmark.
FAU - Lie, Elisabeth
AU  - Lie E
AD  - The Norwegian School of Veterinary Science (NVH), Department of Food Safety and 
      Infection Biology, P.O. Box 5003, Campus Adamstuen, NO-1432 As, Norway.
FAU - Aars, Jon
AU  - Aars J
AD  - Norwegian Polar Institute (NPI), Fram Centre, NO-9296 Tromso, Norway.
FAU - Jenssen, Bjorn M
AU  - Jenssen BM
AD  - Norwegian University of Science and Technology (NTNU), Department of Biology, 
      Hogskoleringen 5, NO-7491 Trondheim, Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150225
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Gonadal Steroid Hormones)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*blood
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Gonadal Steroid Hormones/*blood
MH  - Halogenated Diphenyl Ethers/blood
MH  - Norway
MH  - Pesticides/blood/pharmacology/toxicity
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Tandem Mass Spectrometry
MH  - Ursidae/*metabolism
OTO - NOTNLM
OT  - POPs
OT  - Polar bears
OT  - Steroid hormones
EDAT- 2015/03/01 06:00
MHDA- 2015/06/16 06:00
CRDT- 2015/03/01 06:00
PHST- 2014/09/03 00:00 [received]
PHST- 2015/02/07 00:00 [revised]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/03/01 06:00 [entrez]
PHST- 2015/03/01 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - S0013-9351(15)00039-0 [pii]
AID - 10.1016/j.envres.2015.02.011 [doi]
PST - ppublish
SO  - Environ Res. 2015 Apr;138:191-201. doi: 10.1016/j.envres.2015.02.011. Epub 2015 
      Feb 25.