PMID- 25725302
OWN - NLM
STAT- MEDLINE
DCOM- 20150615
LR  - 20150403
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 138
DP  - 2015 Apr
TI  - Historical exposure to persistent organic pollutants and risk of incident 
      hypertension.
PG  - 217-23
LID - S0013-9351(15)00046-8 [pii]
LID - 10.1016/j.envres.2015.02.018 [doi]
AB  - The aim of this study was to assess the influence of adipose tissue 
      concentrations of a group of persistent organic pollutants (POPs) on the risk of 
      hypertension in an adult cohort of residents of Granada (Southern Spain) over a 
      10-year follow-up. No chemical was significantly associated with the risk of 
      hypertension in the overall population or when models were stratified by sex or 
      median age. However, we found positive associations between log-transformed POP 
      concentrations and hypertension risk in participants with body mass index (BMI) 
      above the median value of 26.3kg/m(2), which were statistically significant for 
      hexachlorobenzene (HR=1.26, 95% CI=1.03-1.56), beta-hexachlorocyclohexane (HR=1.25, 
      95% CI=1.03-1.51), and polychlorinated biphenyl congeners -138 (HR=1.32, 95% 
      CI=1.04-1.69) and -153 (HR=1.36, 95% CI=1.00-1.84). Inverse associations were 
      observed in the subgroup with BMI</=26.3kg/m(2), but none was statistically 
      significant. More research and a longer follow-up period are warranted to verify 
      these associations and elucidate the role of obesity as a potential effect 
      modifier. Given the elevated worldwide frequency of POP exposure and 
      hypertension, the public health impact of this relationship may be substantial.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Arrebola, Juan P
AU  - Arrebola JP
AD  - Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain; 
      Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain; CIBER en Epidemiologia y Salud 
      Publica (CIBERESP), Spain. Electronic address: jparrebola@ugr.es.
FAU - Fernandez, Mariana F
AU  - Fernandez MF
AD  - Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain; CIBER en Epidemiologia y Salud 
      Publica (CIBERESP), Spain.
FAU - Martin-Olmedo, Piedad
AU  - Martin-Olmedo P
AD  - Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria 
      ibs.Granada, Granada, Spain.
FAU - Bonde, Jens Peter
AU  - Bonde JP
AD  - Department of Occupational and Environmental Medicine, Bispebjerg University 
      Hospital, University of Copenhagen, Denmark.
FAU - Martin-Rodriguez, Jose L
AU  - Martin-Rodriguez JL
AD  - Department of Radiology, San Cecilio University Hospital, Granada, Spain.
FAU - Exposito, Jose
AU  - Exposito J
AD  - Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain.
FAU - Rubio-Dominguez, Antonio
AU  - Rubio-Dominguez A
AD  - Gran Capitan Center for Primary Care, Virgen de las Nieves University Hospital, 
      Granada, Spain.
FAU - Olea, Nicolas
AU  - Olea N
AD  - Oncology Unit, Virgen de las Nieves University Hospital, Granada, Spain; 
      Instituto de Investigacion Biosanitaria ibs.Granada, University of Granada, San 
      Cecilio University Hospital, Granada, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150226
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Insecticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/chemistry
MH  - Adult
MH  - Aged
MH  - Blood Pressure/*drug effects
MH  - Body Mass Index
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Humans
MH  - Hydrocarbons, Chlorinated/*toxicity
MH  - Hypertension/chemically induced/*epidemiology
MH  - Insecticides/*toxicity
MH  - Male
MH  - Middle Aged
MH  - Polychlorinated Biphenyls/*toxicity
MH  - Prospective Studies
MH  - Spain/epidemiology
MH  - Young Adult
OTO - NOTNLM
OT  - Adipose tissue
OT  - Hypertension
OT  - Obesity
OT  - Organochlorine pesticides
OT  - Persistent organic pollutants
OT  - Polychlorinated biphenyls
OT  - Prospective study
EDAT- 2015/03/01 06:00
MHDA- 2015/06/16 06:00
CRDT- 2015/03/01 06:00
PHST- 2014/09/15 00:00 [received]
PHST- 2015/01/22 00:00 [revised]
PHST- 2015/02/14 00:00 [accepted]
PHST- 2015/03/01 06:00 [entrez]
PHST- 2015/03/01 06:00 [pubmed]
PHST- 2015/06/16 06:00 [medline]
AID - S0013-9351(15)00046-8 [pii]
AID - 10.1016/j.envres.2015.02.018 [doi]
PST - ppublish
SO  - Environ Res. 2015 Apr;138:217-23. doi: 10.1016/j.envres.2015.02.018. Epub 2015 
      Feb 26.