PMID- 25725564
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20150513
IS  - 1879-1476 (Electronic)
IS  - 0385-8146 (Linking)
VI  - 42
IP  - 4
DP  - 2015 Aug
TI  - Efficacy of low-dose intratympanic dexamethasone for sudden hearing loss.
PG  - 284-7
LID - S0385-8146(15)00026-7 [pii]
LID - 10.1016/j.anl.2015.02.002 [doi]
AB  - OBJECTIVE: Intratympanic steroids (ITSs) are recommended for treatment of sudden 
      sensorineural hearing loss (SSNHL). On the other hand, the dosage, frequency and 
      duration of the intratympanic therapy are still not clear. We aimed to evaluate 
      the efficacy of low-dose intratympanic steroid (ITS) treatment of SSNHL. METHODS: 
      Seventy patients (ears) treated for SSNHL were involved in the study. The 
      patients were divided into four groups: the systemic steroid, combined, 
      intratympanic initial (ITSi) and intratympanic salvage (ITSs). The demographic 
      data, accompanying symptoms, treatment onset duration, the treatment protocol, 
      and pre- and post-treatment pure tone audiometry results were recorded. RESULTS: 
      The mean treatment onset was 60 days in the ITSs group, which is statistically 
      later than the other groups (p<0.001). The treatment response was assessed based 
      on Siegel's criteria. Hearing recovery was statistically higher in the combined 
      group than the systemic steroid group (p=0.042). 87.5% of the ITSi group showed 
      full recovery, which is a statistically significantly higher difference than the 
      other groups (p<0.001). In the salvage treatment group, the use of low-dose ITS 
      was observed to be inadequate for the treatment (p<0.001). The post-treatment 
      pure tone average gains in dB were analyzed at 500, 1000, 2000, and 4000Hz and 
      the recovery determined for each of the four groups was found to be statistically 
      significant (p<0.001 to p<0.031). CONCLUSION: The ITS administration as the 
      initial treatment for mild to moderate hearing loss is adequate while low dose of 
      dexamethasone used as a salvage treatment is inadequate. The use of low-dose ITS 
      in the combined treatment may increase the hearing gain.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Gunel, C
AU  - Gunel C
AD  - Department of Otolaryngology-Head and Neck Surgery, Adnan Menderes University 
      Medical School Hospital, Turkey. Electronic address: drgunel@hotmail.com.
FAU - Basal, Y
AU  - Basal Y
AD  - Department of Otolaryngology-Head and Neck Surgery, Adnan Menderes University 
      Medical School Hospital, Turkey.
FAU - Toka, A
AU  - Toka A
AD  - Department of Otolaryngology-Head and Neck Surgery, Adnan Menderes University 
      Medical School Hospital, Turkey.
FAU - Eryilmaz, A
AU  - Eryilmaz A
AD  - Department of Otolaryngology-Head and Neck Surgery, Adnan Menderes University 
      Medical School Hospital, Turkey.
FAU - Kurt Omurlu, I
AU  - Kurt Omurlu I
AD  - Department of Biostatistic, Adnan Menderes University Medical School Hospital, 
      Turkey.
LA  - eng
PT  - Clinical Study
PT  - Journal Article
DEP - 20150225
PL  - Netherlands
TA  - Auris Nasus Larynx
JT  - Auris, nasus, larynx
JID - 7708170
RN  - 0 (Glucocorticoids)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9PHQ9Y1OLM (Prednisolone)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Audiometry, Pure-Tone
MH  - Combined Modality Therapy
MH  - Dexamethasone/*therapeutic use
MH  - Female
MH  - Glucocorticoids/*therapeutic use
MH  - Hearing Loss, Sudden/*drug therapy
MH  - Humans
MH  - Injection, Intratympanic
MH  - Male
MH  - Middle Aged
MH  - Prednisolone/therapeutic use
MH  - Retrospective Studies
MH  - Salvage Therapy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Intratympanic
OT  - Salvage therapy
OT  - Sensorineural hearing loss
OT  - Steroids
OT  - Sudden hearing loss
EDAT- 2015/03/03 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/03/02 06:00
PHST- 2014/10/13 00:00 [received]
PHST- 2015/01/29 00:00 [revised]
PHST- 2015/02/02 00:00 [accepted]
PHST- 2015/03/02 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - S0385-8146(15)00026-7 [pii]
AID - 10.1016/j.anl.2015.02.002 [doi]
PST - ppublish
SO  - Auris Nasus Larynx. 2015 Aug;42(4):284-7. doi: 10.1016/j.anl.2015.02.002. Epub 
      2015 Feb 25.