PMID- 25725792
OWN - NLM
STAT- MEDLINE
DCOM- 20160125
LR  - 20181113
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
VI  - 404
IP  - 1-2
DP  - 2015 Jun
TI  - The E23K and A190A variations of the KCNJ11 gene are associated with early-onset 
      type 2 diabetes and blood pressure in the Chinese population.
PG  - 133-41
LID - 10.1007/s11010-015-2373-7 [doi]
AB  - Conflicting associations between define (KCNJ11) variations and susceptibility to 
      late-onset (>40 years old) type 2 diabetes mellitus (T2DM) have been reported in 
      different ethnic groups. We investigated whether the E23K (G-->A, rs5219) or A190A 
      (C-->T, rs5218) variations in KCNJ11 are associated with early-onset T2DM and blood 
      pressure in the Chinese population. Case-control study of 175 unrelated Chinese 
      patients with early-onset T2DM (age of onset <40 years old) who receive (ins+, n 
      = 57) or do not receive insulin (ins-, n = 118), and 182 non-diabetic control 
      subjects. PCR-direct sequencing was performed to genotype E23K and A190A; the 
      genotypic frequencies and associations with clinical characteristics were 
      analyzed. The genotypic frequencies of E23K-GA+AA were higher and A190A-TT was 
      lower in the early-onset T2DM group, especially the T2D-ins+ group, compared to 
      the non-diabetic control group (p < 0.01 or 0.05, respectively). In non-diabetic 
      subjects, E23K-AA carriers had significantly higher 2 h plasma glucose and lower 
      2 h insulin than E23K-GG carriers (both p < 0.05). A190A-TT or E23K-GG carriers 
      had higher systolic blood pressure (SBP) than CC or AA carriers in the 
      non-diabetic control and T2DM groups (both p < 0.05). In the T2DM ins+ group, 
      E23K-AA carriers had lower onset age and duration of diabetes and higher BMI than 
      GG carriers, and A190A-TT carriers had higher SBP than CC carriers (all p < 
      0.05). The E23K-GA or AA genotypes may increase the susceptibility to early-onset 
      T2DM, while A190A-TT may protect against early-onset T2DM. On the other hand the 
      A190A-TT or E23K-GG genotypes may increase the risk of hypertension in the 
      Chinese population.
FAU - Zhuang, Langen
AU  - Zhuang L
AD  - Department of Endocrinology & Metabolism, Shanghai Jiaotong University Affiliated 
      Sixth People's Hospital, Shanghai Diabetes Institute, 600 Yishan Road, Shanghai, 
      200233, China.
FAU - Zhao, Yu
AU  - Zhao Y
FAU - Zhao, Weijing
AU  - Zhao W
FAU - Li, Ming
AU  - Li M
FAU - Yu, Ming
AU  - Yu M
FAU - Lu, Ming
AU  - Lu M
FAU - Zhang, Rong
AU  - Zhang R
FAU - Ge, Xiaoxu
AU  - Ge X
FAU - Zheng, Taishan
AU  - Zheng T
FAU - Li, Can
AU  - Li C
FAU - Yin, Jun
AU  - Yin J
FAU - Yin, Jingyuan
AU  - Yin J
FAU - Bao, Yuqian
AU  - Bao Y
FAU - Liu, Limei
AU  - Liu L
FAU - Jia, Weiping
AU  - Jia W
FAU - Liu, Yanjun
AU  - Liu Y
LA  - eng
GR  - SC1DK087655/DK/NIDDK NIH HHS/United States
GR  - SC1DK104821/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150301
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Kir6.2 channel)
RN  - 0 (Potassium Channels, Inwardly Rectifying)
SB  - IM
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Blood Pressure/genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics/pathology
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Hypertension/*genetics/pathology
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Potassium Channels, Inwardly Rectifying/*genetics
EDAT- 2015/03/03 06:00
MHDA- 2016/01/26 06:00
CRDT- 2015/03/02 06:00
PHST- 2014/11/25 00:00 [received]
PHST- 2015/02/23 00:00 [accepted]
PHST- 2015/03/02 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/01/26 06:00 [medline]
AID - 10.1007/s11010-015-2373-7 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2015 Jun;404(1-2):133-41. doi: 10.1007/s11010-015-2373-7. Epub 
      2015 Mar 1.