PMID- 25725813
OWN - NLM
STAT- MEDLINE
DCOM- 20160315
LR  - 20181113
IS  - 1559-131X (Electronic)
IS  - 1357-0560 (Linking)
VI  - 32
IP  - 4
DP  - 2015 Apr
TI  - Intensity-modulated radiotherapy and volumetric-modulated arc therapy have 
      distinct clinical advantages in non-small cell lung cancer treatment.
PG  - 94
LID - 10.1007/s12032-015-0546-6 [doi]
AB  - This study was conducted to compare the efficacy of intensity-modulated 
      radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) in delivering the 
      planned dosage in the treatment of non-small cell lung cancer (NSCLC). Between 
      September 2013 and March 2014, 125 NSCLC patients were randomly chosen and 
      allocated to the IMRT group (n = 65) and VMAT group (n = 60). We compared 
      multiple parameters such as target dose, organ dosimetry, monitor unit (MU) and 
      time of therapy between IMRT and VMAT groups. The prescribed dose coverage of 
      both planning techniques was 95 % of the planning target volumes (PTVs). PTV 95 % 
      and homogeneous index in IMRT plan were greater than those in VMAT plan (both P < 
      0.05), while no significant difference in conformity index was observed (P > 
      0.05). The mean total lung V5 and V10 in VMAT group were markedly higher than 
      those in IMRT group, but the V20, V30, and V40 in VMAT group were significantly 
      lower (all P < 0.05), but no statistically significant difference was observed in 
      V15 and V20 (P > 0.05). Furthermore, the planning spine and esophagus at risk 
      volume showed no statistical significances in both groups (P > 0.05). MU of IMRT 
      plan was about 4.2 % less than that of VMAT plan, which was statistically 
      significant (P < 0.001). Both IMRT and VMAT had significant advantages in the 
      treatment of NSCLC. The IMRT may be better for NSCLC patients with poor pulmonary 
      function, and VMAT may be recommended for NSCLC patients with normal pulmonary 
      function.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Department of Respiratory Disease, The Fourth Affiliated Hospital of China 
      Medical University, No. 102 Nan Qi Road, He Ping District, Shen Yang, 110005, 
      Liao Ning Province, People's Republic of China, zhangjun_1204@126.com.
FAU - Yu, Xiao-Ling
AU  - Yu XL
FAU - Zheng, Guo-Feng
AU  - Zheng GF
FAU - Zhao, Fei
AU  - Zhao F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150301
PL  - United States
TA  - Med Oncol
JT  - Medical oncology (Northwood, London, England)
JID - 9435512
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/pathology/*radiotherapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lung Neoplasms/pathology/*radiotherapy
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted/*methods
MH  - Radiotherapy, Intensity-Modulated/*methods
EDAT- 2015/03/03 06:00
MHDA- 2016/03/16 06:00
CRDT- 2015/03/02 06:00
PHST- 2015/01/29 00:00 [received]
PHST- 2015/02/13 00:00 [accepted]
PHST- 2015/03/02 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/03/16 06:00 [medline]
AID - 10.1007/s12032-015-0546-6 [doi]
PST - ppublish
SO  - Med Oncol. 2015 Apr;32(4):94. doi: 10.1007/s12032-015-0546-6. Epub 2015 Mar 1.