PMID- 25726897
OWN - NLM
STAT- MEDLINE
DCOM- 20160104
LR  - 20150419
IS  - 1873-3514 (Electronic)
IS  - 0028-3932 (Linking)
VI  - 70
DP  - 2015 Apr
TI  - Rapid feedback processing in human nucleus accumbens and motor thalamus.
PG  - 246-54
LID - S0028-3932(15)00099-8 [pii]
LID - 10.1016/j.neuropsychologia.2015.02.032 [doi]
AB  - The nucleus accumbens (NAcc) and thalamus are integral parts in models of 
      feedback processing. Deep brain stimulation (DBS) has been successfully employed 
      to alleviate symptoms of psychiatric conditions including obsessive-compulsive 
      disorder (OCD) and Tourette's syndrome (TS). Common target structures are the 
      NAcc and the ventral anterior and ventro-lateral nuclei (VA/VL) of the thalamus, 
      for OCD and TS, respectively. The feedback related negativity (FRN) is an 
      event-related potential associated with feedback processing reflecting posterior 
      medial frontal cortex (pMFC) activity. Here we report on three cases where we 
      recorded scalp EEG and local field potentials (LFP) from externalized electrodes 
      located in the NAcc or thalamus (VA/VL) while patients engaged in a modified time 
      estimation task, known to engage feedback processing and elicit the FRN. 
      Additionally, scalp EEG were recorded from 29 healthy participants (HP) engaged 
      in the same task. The signal in all structures (pMFC, NAcc, and thalamus) was 
      differently modulated by positive and negative feedback. LFP activity in the NAcc 
      showed a biphasic time course after positive feedback during the FRN time 
      interval. Negative feedback elicited a much weaker and later response. In the 
      thalamus a monophasic modulation was recorded during the FRN time interval. 
      Again, this modulation was more pronounced after positive performance feedback 
      compared to negative feedback. In channels outside the target area no modulation 
      was observed. The surface-FRN was reliably elicited on a group level in HP and 
      showed no significant difference following negative feedback between patients and 
      HP. German Clinical Trial Register: Neurocognitive specification of dysfunctions 
      within basal ganglia-cortex loops and their therapeutic modulation by deep brain 
      stimulation in patients with obsessive compulsive disorder and Tourette syndrome, 
      http://www.drks.de/DRKS00005316.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Schuller, Thomas
AU  - Schuller T
AD  - University Hospital of Cologne, Department of Psychiatry and 
      Psychotherapy, Kerpener Strasse 62, 50937 Cologne, Germany. Electronic address: 
      thomas.schueller@uk-koeln.de.
FAU - Gruendler, Theo O J
AU  - Gruendler TO
AD  - University Hospital of Cologne, Department of Psychiatry and 
      Psychotherapy, Kerpener Strasse 62, 50937 Cologne, Germany; Otto von Guericke 
      University, Faculty of Economics and Management, Magdeburg, Germany; Center for 
      Behavioral Brain Sciences, Magdeburg, Germany.
FAU - Jocham, Gerhard
AU  - Jocham G
AD  - Otto von Guericke University, Faculty of Economics and Management, Magdeburg, 
      Germany; Center for Behavioral Brain Sciences, Magdeburg, Germany.
FAU - Klein, Tilmann A
AU  - Klein TA
AD  - Max-Planck-Institute for Human Cognitive and Brain Sciences, Department of 
      Neurology, Leipzig, Germany; Day Clinic for Cognitive Neurology, University 
      Clinic Leipzig, Leipzig, Germany.
FAU - Timmermann, Lars
AU  - Timmermann L
AD  - University Hospital of Cologne, Department of Neurology, Cologne, Germany.
FAU - Visser-Vandewalle, Veerle
AU  - Visser-Vandewalle V
AD  - University Hospital of Cologne, Department of Stereotaxy and Functional 
      Neurosurgery, Cologne, Germany.
FAU - Kuhn, Jens
AU  - Kuhn J
AD  - University Hospital of Cologne, Department of Psychiatry and 
      Psychotherapy, Kerpener Strasse 62, 50937 Cologne, Germany.
FAU - Ullsperger, Markus
AU  - Ullsperger M
AD  - Center for Behavioral Brain Sciences, Magdeburg, Germany; Otto von Guericke 
      University, Institute of Psychology II, Magdeburg, Germany; Radboud University 
      Nijmegen, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The 
      Netherlands.
LA  - eng
SI  - DRKS/DRKS00005316
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150226
PL  - England
TA  - Neuropsychologia
JT  - Neuropsychologia
JID - 0020713
SB  - IM
MH  - Adult
MH  - Brain Mapping
MH  - Deep Brain Stimulation/*methods
MH  - Electroencephalography
MH  - Evoked Potentials/physiology
MH  - Feedback, Physiological/*physiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Nucleus Accumbens/*physiology
MH  - Obsessive-Compulsive Disorder/therapy
MH  - Photic Stimulation
MH  - Thalamus/*physiology
MH  - Tourette Syndrome/therapy
OTO - NOTNLM
OT  - Deep brain Stimulation
OT  - Feedback-related negativity
OT  - Nucleus accumbens
OT  - Performance monitoring
OT  - Thalamus
OT  - Time estimation task
EDAT- 2015/03/03 06:00
MHDA- 2016/01/05 06:00
CRDT- 2015/03/03 06:00
PHST- 2014/11/05 00:00 [received]
PHST- 2015/02/19 00:00 [revised]
PHST- 2015/02/21 00:00 [accepted]
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/01/05 06:00 [medline]
AID - S0028-3932(15)00099-8 [pii]
AID - 10.1016/j.neuropsychologia.2015.02.032 [doi]
PST - ppublish
SO  - Neuropsychologia. 2015 Apr;70:246-54. doi: 
      10.1016/j.neuropsychologia.2015.02.032. Epub 2015 Feb 26.