PMID- 25727025
OWN - NLM
STAT- MEDLINE
DCOM- 20160112
LR  - 20220408
IS  - 1678-4782 (Electronic)
IS  - 0021-7557 (Linking)
VI  - 91
IP  - 4
DP  - 2015 Jul-Aug
TI  - Association of neopterin as a marker of immune system activation and juvenile 
      rheumatoid arthritis activity.
PG  - 352-7
LID - S0021-7557(15)00017-0 [pii]
LID - 10.1016/j.jped.2014.09.007 [doi]
AB  - OBJECTIVE: To evaluate neopterin plasma concentrations in patients with active 
      juvenile idiopathic arthritis (JIA) and correlate them with disease activity. 
      METHODS: Sixty patients diagnosed as active JIA, as well as another 60 apparently 
      healthy age- and gender-matched children as controls, were recruited from the 
      Pediatrics Allergy and Immunology Clinic, Ain Shams University. Disease activity 
      was assessed by the Juvenile Arthritis Disease Activity Score 27 (JADAS-27). 
      Laboratory investigations were performed for all patients, including 
      determination of hemoglobin concentration (Hgb), erythrocyte sedimentation rate 
      (ESR), and C-reactive protein. Serum concentrations of tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemoattractant protein-1 
      (MCP-1), and neopterin were measured. RESULTS: Significant differences were found 
      between JIA patients and controls with regard to the mean levels of Hgb, ESR, 
      TNF-alpha, IL-6, and MCP-1 (p<0.05). A statistically significant higher mean level 
      serum neopterin concentration (p<0.05) was found in JIA patients (20.43+/-8.73 
      nmol/L) than in controls (6.88+/-2.87 nmol/L) (p<0.05). Positive significant 
      correlations were detected between serum neopterin and ESR, TNF-alpha, IL-6, MCP-1, 
      and JADAS-27 (p<0.05). No correlation was found between serum neopterin and CRP 
      (p>0.05). Multiple linear regression analysis showed that JADAS- 27 and ESR were 
      the main variables associated with serum neopterin in JIA patients (p<0.05). 
      CONCLUSION: The elevation of plasma neopterin concentrations in early JIA 
      patients may indicate stimulation of immune response. Serum neopterin can be used 
      as a sensitive marker for assaying background inflammation and disease activity 
      score in JIA patients.
CI  - Copyright (c) 2015 Sociedade Brasileira de Pediatria. Published by Elsevier Editora 
      Ltda. All rights reserved.
FAU - Shady, Mones M Abu
AU  - Shady MM
AD  - Child Health Department, Medical Division, National Research Centre, Cairo, 
      Egypt.
FAU - Fathy, Hanan A
AU  - Fathy HA
AD  - Health Research Department, National Research Centre, Cairo, Egypt.
FAU - Ali, Alaa
AU  - Ali A
AD  - Child Health Department, Medical Division, National Research Centre, Cairo, 
      Egypt.
FAU - Youness, Eman R
AU  - Youness ER
AD  - Medical Biochemistry Division, National Center for Radiation and Technology, 
      Cairo, Egypt. Electronic address: hoctober2000@yahoo.com.
FAU - Fathy, Gihan A
AU  - Fathy GA
AD  - Child Health Department, Medical Division, National Research Centre, Cairo, 
      Egypt.
LA  - eng
PT  - Journal Article
DEP - 20150226
PL  - Brazil
TA  - J Pediatr (Rio J)
JT  - Jornal de pediatria
JID - 2985188R
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 670-65-5 (Neopterin)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
EIN - J Pediatr (Rio J). 2015 Sep-Oct;91(5):508
MH  - Adolescent
MH  - Arthritis, Juvenile/*blood/immunology
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - C-Reactive Protein/analysis
MH  - Case-Control Studies
MH  - Chemokine CCL2/analysis
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Interleukin-6/immunology
MH  - Macrophage Activation
MH  - Male
MH  - Neopterin/*blood
MH  - Predictive Value of Tests
MH  - Severity of Illness Index
MH  - Tumor Necrosis Factor-alpha/blood
OTO - NOTNLM
OT  - Artrite reumatoide
OT  - FNT-alpha
OT  - MCP-1
OT  - Rheumatoid arthritis
OT  - TNF-alpha
EDAT- 2015/03/03 06:00
MHDA- 2016/01/13 06:00
CRDT- 2015/03/03 06:00
PHST- 2014/03/13 00:00 [received]
PHST- 2014/08/31 00:00 [revised]
PHST- 2014/09/10 00:00 [accepted]
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/01/13 06:00 [medline]
AID - S0021-7557(15)00017-0 [pii]
AID - 10.1016/j.jped.2014.09.007 [doi]
PST - ppublish
SO  - J Pediatr (Rio J). 2015 Jul-Aug;91(4):352-7. doi: 10.1016/j.jped.2014.09.007. 
      Epub 2015 Feb 26.