PMID- 25728141
OWN - NLM
STAT- MEDLINE
DCOM- 20150526
LR  - 20151119
IS  - 1879-1190 (Electronic)
IS  - 1072-7515 (Linking)
VI  - 220
IP  - 4
DP  - 2015 Apr
TI  - How are select chronic pancreatitis patients selected for total pancreatectomy 
      with islet autotransplantation? Are there psychometric predictors?
PG  - 693-8
LID - S1072-7515(15)00005-8 [pii]
LID - 10.1016/j.jamcollsurg.2014.12.035 [doi]
AB  - BACKGROUND: Selected patients with chronic pancreatitis can benefit from total 
      pancreatectomy with islet autotransplantation. Patient selection is challenging 
      and outcomes assessment is essential. STUDY DESIGN: A prospective database of 
      total pancreatectomy with islet autotransplantation patients was reviewed. 
      Attention was given to psychometric assessments, including Short Form-12 Quality 
      of Life Survey (SF-12), Center for Epidemiologic Studies 10-Item Depression 
      scale, and Current Opioid Misuse Measure in the preoperative period, and SF-12 in 
      the postoperative period. RESULTS: One hundred and twenty-seven patients (76% 
      women, mean age 40.5 years) underwent total pancreatectomy with islet 
      autotransplantation. Preoperatively, the mean SF-12 physical quality of life 
      score (physQOL) was 27.24 (SD 9.9) and the mean psychological QOL score 
      (psychQOL) was 38.5 (SD 12.8), with a score of 50 representing the mean of a 
      healthy population. Mean improvements in physQOL relative to baseline at 1 year, 
      2 years, and 3 years post surgery were 7.1, 5.8, and 7.8, respectively, which 
      represented significant change (all p < 0.001). Mean improvements in psychQOL 
      relative to baseline at 1 year, 2 years, and 3 years post surgery were 3.9, 4.9, 
      and 6.6, which also represented significant improvement (all p < 0.001). The 
      percentages of patients evidencing at least a 3-point improvement in physQOL at 1 
      year, 2 years, and 3 years post surgery were 65%, 60%, and 61%, respectively. The 
      percentages of patients evidencing at least a 3-point improvement in psychQOL at 
      1 year, 2 years, and 3 years post surgery were 49%, 58%, and 66%, respectively. 
      Exploratory regression analyses of SF-12, Current Opioid Misuse Measure, and 
      Center for Epidemiologic Studies 10-Item Depression scale data revealed limited 
      baseline predictability of surgical response; however, higher opioid misuse 
      scores at baseline were significantly and positively related to physQOL 
      improvement at 2 years (r[54] = 0.33, p = 0.02). CONCLUSIONS: Total 
      pancreatectomy with islet autotransplantation improves QOL for selected patients 
      with chronic pancreatitis. The physQOL improves quickly after surgery, and 
      psychQOL improvements are more gradual. Opioid misuse can predict physQOL 
      improvement.
CI  - Copyright (c) 2015 American College of Surgeons. Published by Elsevier Inc. All 
      rights reserved.
FAU - Morgan, Katherine A
AU  - Morgan KA
AD  - Department of Surgery, Medical University of South Carolina, Charleston, SC. 
      Electronic address: morganka@musc.edu.
FAU - Borckardt, Jeffrey
AU  - Borckardt J
AD  - Department of Psychology and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, SC.
FAU - Balliet, Wendy
AU  - Balliet W
AD  - Department of Psychology and Behavioral Sciences, Medical University of South 
      Carolina, Charleston, SC.
FAU - Owczarski, Stefanie M
AU  - Owczarski SM
AD  - Department of Surgery, Medical University of South Carolina, Charleston, SC.
FAU - Adams, David B
AU  - Adams DB
AD  - Department of Surgery, Medical University of South Carolina, Charleston, SC.
LA  - eng
PT  - Journal Article
DEP - 20150106
PL  - United States
TA  - J Am Coll Surg
JT  - Journal of the American College of Surgeons
JID - 9431305
SB  - IM
CIN - J Am Coll Surg. 2015 Apr;220(4):698-700. PMID: 25797756
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Islets of Langerhans Transplantation/*methods
MH  - Male
MH  - Middle Aged
MH  - Pancreatectomy/*methods
MH  - Pancreatitis, Chronic/psychology/*surgery
MH  - *Patient Selection
MH  - Postoperative Period
MH  - Prospective Studies
MH  - Psychometrics/*methods
MH  - *Quality of Life
MH  - Surveys and Questionnaires
MH  - Transplantation, Autologous
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2015/03/03 06:00
MHDA- 2015/05/27 06:00
CRDT- 2015/03/03 06:00
PHST- 2014/12/06 00:00 [received]
PHST- 2014/12/09 00:00 [accepted]
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2015/05/27 06:00 [medline]
AID - S1072-7515(15)00005-8 [pii]
AID - 10.1016/j.jamcollsurg.2014.12.035 [doi]
PST - ppublish
SO  - J Am Coll Surg. 2015 Apr;220(4):693-8. doi: 10.1016/j.jamcollsurg.2014.12.035. 
      Epub 2015 Jan 6.