PMID- 25728833 OWN - NLM STAT- MEDLINE DCOM- 20160323 LR - 20191210 IS - 1573-2509 (Electronic) IS - 0920-9964 (Print) IS - 0920-9964 (Linking) VI - 164 IP - 1-3 DP - 2015 May TI - Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis. PG - 1-7 LID - S0920-9964(15)00060-2 [pii] LID - 10.1016/j.schres.2015.01.030 [doi] AB - BACKGROUND: There is a growing recognition that individuals at clinical high risk need intervention for functional impairments, along with emerging psychosis, as the majority of clinical high risk (CHR) individuals show persistent deficits in social and role functioning regardless of transition to psychosis. Recent studies have demonstrated reduced reading ability as a potential cause of functional disability in schizophrenia, related to underlying deficits in generation of mismatch negativity (MMN). The present study extends these findings to subjects at CHR. METHODS: The sample consisted of 34 CHR individuals and 33 healthy comparison subjects (CNTLs) from the Recognition and Prevention (RAP) Program at the Zucker Hillside Hospital in New York. At baseline, reading measures were collected, along with MMN to pitch, duration, and intensity deviants, and measures of neurocognition, and social and role (academic/work) functioning. RESULTS: CHR subjects showed impairments in reading ability, neurocognition, and MMN generation, relative to CNTLs. Lower-amplitude MMN responses were correlated with worse reading ability, slower processing speed, and poorer social and role functioning. However, when entered into a simultaneous regression, only reduced responses to deviance in sound duration and volume predicted poor social and role functioning, respectively. CONCLUSIONS: Deficits in reading ability exist even prior to illness onset in schizophrenia and may represent a decline in performance from prior abilities. As in schizophrenia, deficits are related to impaired MMN generation, suggesting specific contributions of sensory-level impairment to neurocognitive processes related to social and role function. CI - Copyright (c) 2015 Elsevier B.V. All rights reserved. FAU - Carrion, Ricardo E AU - Carrion RE AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA; Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA; Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. Electronic address: RCarrion@NSHS.edu. FAU - Cornblatt, Barbara A AU - Cornblatt BA AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA; Center for Psychiatric Neuroscience, The Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, USA; Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA; Department of Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - McLaughlin, Danielle AU - McLaughlin D AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA. FAU - Chang, Jeremy AU - Chang J AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA. FAU - Auther, Andrea M AU - Auther AM AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA; Department of Psychiatry, Hofstra North Shore-LIJ School of Medicine, Hempstead, NY, USA. FAU - Olsen, Ruth H AU - Olsen RH AD - Division of Psychiatry Research, The Zucker Hillside Hospital, North Shore-Long Island Jewish Health System (NS-LIJHS), Glen Oaks, NY, USA. FAU - Javitt, Daniel C AU - Javitt DC AD - Division of Experimental Therapeutics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA; Division of Schizophrenia Research, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA. LA - eng GR - R01 MH049334/MH/NIMH NIH HHS/United States GR - R01 MH061523/MH/NIMH NIH HHS/United States GR - MH 074543/MH/NIMH NIH HHS/United States GR - P30 MH074543/MH/NIMH NIH HHS/United States GR - MH086385/MH/NIMH NIH HHS/United States GR - MH61523/MH/NIMH NIH HHS/United States GR - P50 MH086385/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20150223 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Acoustic Stimulation MH - Adolescent MH - Adult MH - Analysis of Variance MH - Cerebral Cortex/*physiopathology MH - Chi-Square Distribution MH - Child MH - Contingent Negative Variation/*physiology MH - Cross-Sectional Studies MH - Electroencephalography MH - Female MH - Humans MH - Longitudinal Studies MH - Male MH - Neuropsychological Tests MH - Prodromal Symptoms MH - Psychiatric Status Rating Scales MH - Psychotic Disorders/*pathology/*physiopathology MH - *Reading MH - Recognition, Psychology/*physiology MH - Young Adult PMC - PMC4469046 MID - NIHMS667100 OTO - NOTNLM OT - Clinical high risk OT - Early intervention OT - Mismatch negativity OT - Reading OT - Social functioning EDAT- 2015/03/03 06:00 MHDA- 2016/03/24 06:00 PMCR- 2016/05/01 CRDT- 2015/03/03 06:00 PHST- 2014/10/14 00:00 [received] PHST- 2015/01/17 00:00 [revised] PHST- 2015/01/19 00:00 [accepted] PHST- 2015/03/03 06:00 [entrez] PHST- 2015/03/03 06:00 [pubmed] PHST- 2016/03/24 06:00 [medline] PHST- 2016/05/01 00:00 [pmc-release] AID - S0920-9964(15)00060-2 [pii] AID - 10.1016/j.schres.2015.01.030 [doi] PST - ppublish SO - Schizophr Res. 2015 May;164(1-3):1-7. doi: 10.1016/j.schres.2015.01.030. Epub 2015 Feb 23.