PMID- 25729618
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150302
LR  - 20201001
IS  - 2092-7355 (Print)
IS  - 2092-7363 (Electronic)
IS  - 2092-7355 (Linking)
VI  - 7
IP  - 2
DP  - 2015 Mar
TI  - Three-Year Follow-up Results of Sublingual Immunotherapy in Patients With 
      Allergic Rhinitis Sensitized to House Dust Mites.
PG  - 118-23
LID - 10.4168/aair.2015.7.2.118 [doi]
AB  - PURPOSE: This study investigated the long-term efficacy, safety, and compliance 
      associated with sublingual immunotherapy (SLIT) in Korean patients with allergic 
      rhinitis sensitized to house dust mites. METHODS: This is a retrospective cohort 
      study. A total of 164 patients who were sensitized to Dermatophagoides 
      pteronyssinus and Dermatophagoides farinae and who received SLIT were enrolled 
      between November 2007 and January 2010. Each patient was followed up using a 
      diary card, on which a symptom score, rescue medication score, and adverse events 
      (AEs) were recorded. RESULTS: All allergic rhinitis symptoms improved after 3 
      years of SLIT (P<0.05), and the rescue medication score decreased with time 
      (P<0.05). The incidence of AEs associated with SLIT was 31% (51 of 164 patients) 
      during the first month of therapy, and there were no severe AEs. The dropout rate 
      was 19.5% (32 of 164 patients) during the first month, 34% (56 of 164 patients) 
      after 6 months, and 41% (68 of 164 patients) after 1 year of SLIT. The 3-year 
      compliance rate was approximately 40% (65 of 164 patients). The most common 
      causes of dropout during the first month of SLIT were high cost and 
      inconvenience. The improvement in allergic symptoms was the most common cause of 
      dropout after 6 months. CONCLUSIONS: Allergic symptoms significantly decreased 
      after 1 year of SLIT treatment, and this effect was sustained after 2 or 3 years 
      of treatment. By increasing compliance through patient education, the 3-year use 
      of SLIT for house dust mite allergies may be effective in the management of 
      allergic rhinitis.
FAU - Kim, Shin Hye
AU  - Kim SH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Mun, Sue Jean
AU  - Mun SJ
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Han, Doo Hee
AU  - Han DH
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Kim, Jeong-Whun
AU  - Kim JW
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seongnam, Korea.
FAU - Kim, Dong-Young
AU  - Kim DY
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Rhee, Chae-Seo
AU  - Rhee CS
AD  - Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National 
      University Bundang Hospital, Seongnam, Korea. ; Graduate School of Immunology, 
      Seoul National University, Seoul, Korea. ; Sensory Organ Research Institute, 
      Seoul National University, Seoul, Korea. ; Institute of Allergy and Clinical 
      Immunology, Seoul National University Biomedical Research Institute, Seoul, 
      Korea.
LA  - eng
PT  - Journal Article
DEP - 20141030
PL  - Korea (South)
TA  - Allergy Asthma Immunol Res
JT  - Allergy, asthma & immunology research
JID - 101518382
PMC - PMC4341332
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - compliance
OT  - efficacy
OT  - house dust mites
OT  - safety
OT  - sublingual immunotherapy
COIS- There are no financial or other issues that might lead to conflict of interest.
EDAT- 2015/03/03 06:00
MHDA- 2015/03/03 06:01
PMCR- 2015/03/01
CRDT- 2015/03/03 06:00
PHST- 2014/02/01 00:00 [received]
PHST- 2014/05/27 00:00 [revised]
PHST- 2014/06/18 00:00 [accepted]
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2015/03/03 06:01 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 10.4168/aair.2015.7.2.118 [doi]
PST - ppublish
SO  - Allergy Asthma Immunol Res. 2015 Mar;7(2):118-23. doi: 10.4168/aair.2015.7.2.118. 
      Epub 2014 Oct 30.