PMID- 25729961
OWN - NLM
STAT- MEDLINE
DCOM- 20160120
LR  - 20150303
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 1
DP  - 2015 Jan 23
TI  - Genetic association between the HLA-G 14-bp insertion/deletion polymorphism and 
      the recurrent spontaneous abortions in Saudi Arabian women.
PG  - 286-93
LID - 10.4238/2015.January.23.2 [doi]
AB  - The non-classical class I human leukocyte antigen (HLA)-G molecule was found to 
      be predominately expressed in the extravillous cytotrophoblasts at the 
      fetal-maternal interface during pregnancy. This molecule is critically important 
      for successful implantation during human pregnancy. The polymorphic 
      insertion-deletion (indel) 14-base pair (bp) site localized at the 3' 
      untranslated region was associated with HLA-G mRNA stability and isoform 
      alternative splicing patterns, and thus may influence HLA-G function during 
      pregnancy. We studied the association between the 14-bp indel polymorphism 
      (rs16375) at the 3' untranslated region with recurrent spontaneous abortions in a 
      Saudi population living in Riyadh. A group of 64 women with 2-11 successive 
      abortions were included in this study. The control group included 62 women 
      without reported abortions and at least 2 pregnancies, all visiting the King 
      Khaled Hospital in Riyadh. The 14-bp indel was genotyped in the case and control 
      groups. The frequency of the genotype +14/+14 was slightly higher in women with 
      recurrent spontaneous abortions, but no significant differences were observed in 
      the distribution of alleles and genotypes.
FAU - Al Omar, S Y
AU  - Al Omar SY
AD  - Department of Zoology, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Mansour, L
AU  - Mansour L
AD  - Department of Zoology, College of Science, King Saud University, Riyadh, Saudi 
      Arabia lamjed.mansour@gmail.com.
FAU - Alkhuriji, A F
AU  - Alkhuriji AF
AD  - Department of Zoology, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Alwasel, S
AU  - Alwasel S
AD  - Department of Zoology, College of Science, King Saud University, Riyadh, Saudi 
      Arabia.
FAU - Al-Qahtani, S
AU  - Al-Qahtani S
AD  - Depatment of Physiology, College of Medicine, Jazan University, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150123
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (HLA-G Antigens)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Adult
MH  - Alleles
MH  - Base Pairing/*genetics
MH  - Case-Control Studies
MH  - Female
MH  - Gene Frequency/genetics
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - HLA-G Antigens/*genetics
MH  - Humans
MH  - INDEL Mutation/*genetics
MH  - *Polymorphism, Genetic
MH  - Pregnancy
EDAT- 2015/03/03 06:00
MHDA- 2016/01/21 06:00
CRDT- 2015/03/03 06:00
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/01/21 06:00 [medline]
AID - gmr4590 [pii]
AID - 10.4238/2015.January.23.2 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Jan 23;14(1):286-93. doi: 10.4238/2015.January.23.2.