PMID- 25729992
OWN - NLM
STAT- MEDLINE
DCOM- 20160120
LR  - 20220321
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 1
DP  - 2015 Jan 26
TI  - TNF-alphaG-308A polymorphism is associated with insulin resistance: a meta-analysis.
PG  - 563-73
LID - 10.4238/2015.January.26.11 [doi]
AB  - Tumor necrosis factor-alpha (TNF-alpha) promoter polymorphisms has been reported to be 
      associated with obesity and insulin resistance and gained widespread attention. 
      However, results obtained so far are quite conf‍‍licting. We therefore performed 
      a meta-analysis to address this issue, basing on 17 studies from electronic 
      databases (MEDLINE and EMBASE). No evidence of significant effect of TNF-alphaG-308A 
      polymorphism on body mass index (BMI) or obesity risk was detected (BMI: WMDRE = 
      0.05, 95%CI: -0.62 to 0.73; risk of obesity: ORFE = 1.09, 95%CI: 0.87 to 1.35). 
      G-308A variant was significantly associated with increased insulin levels in the 
      overall (SMDFE = 0.12, 95%CI: 0.03 to 0.20) and obese subgroup analysis (SMDFE = 
      0.16, 95%CI: 0.03 to 0.29). In total, no significant result was observed for the 
      association between TNF-alpha G-308A variant and HOMA-IR index. Nevertheless, 
      subgroup analysis showed G-308A polymorphism was significantly associated with 
      increased HOMA-IR in Caucasians (WMDFE = 0.49, 95%CI: 0.03 to 0.94). Our results 
      indicate that TNF-alphaG-308A polymorphism has a significant effect on insulin 
      resistance. However, it is unlikely that G-308A variant contributes to obesity.
FAU - Wang, H G
AU  - Wang HG
AD  - Institute of Immunopharmacology and Immunotherapy, School of Pharmacy, Shandong 
      University, Jinan, China.
FAU - Yang, J
AU  - Yang J
AD  - Department of Pediatric, Qilu Hospital, Shandong University, Jinan, China.
FAU - Han, H
AU  - Han H
AD  - Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
FAU - Xu, F
AU  - Xu F
AD  - Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
FAU - Bian, Y
AU  - Bian Y
AD  - Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
FAU - Zhang, H
AU  - Zhang H
AD  - Department of Emergency, Qilu Hospital, Shandong University, Jinan, China.
FAU - Wang, J L
AU  - Wang JL
AD  - Department of Emergency, Qilu Hospital, Shandong University, Jinan, China 
      wangjiali_2000@126.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150126
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Insulin)
RN  - 0 (TNF protein, human)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Body Mass Index
MH  - Female
MH  - *Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*genetics
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/genetics
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Publication Bias
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*genetics
MH  - Young Adult
EDAT- 2015/03/03 06:00
MHDA- 2016/01/21 06:00
CRDT- 2015/03/03 06:00
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2016/01/21 06:00 [medline]
AID - gmr4467 [pii]
AID - 10.4238/2015.January.26.11 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Jan 26;14(1):563-73. doi: 10.4238/2015.January.26.11.