PMID- 2573011
OWN - NLM
STAT- MEDLINE
DCOM- 19891220
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 104
IP  - 1-2
DP  - 1989 Sep 25
TI  - Reserpine does not prevent 3,4-methylenedioxymethamphetamine-induced 
      neurotoxicity in the rat.
PG  - 178-82
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a known neurotoxin to 
      5-hydroxytryptamine (5-HT) nerve terminals. Recent studies have suggested that 
      endogenous dopamine (DA) and/or 5-HT may mediate the MDMA-induced neurotoxicity. 
      The central monoamine stores of rats were significantly decreased with reserpine 
      (5 mg/kg) prior to toxic injections of MDMA. Rats given MDMA (30 mg/kg) displayed 
      significant decreases in the density of 5-HT nerve terminals labeled by 
      [3H]paroxetine both with (51 +/- 8%) and without (43 +/- 20%) reserpine 
      pre-treatment. These data suggest that the degeneration of 5-HT nerve terminals 
      following MDMA is independent of the presence of endogenous stores of DA or 5-HT.
FAU - Hekmatpanah, C R
AU  - Hekmatpanah CR
AD  - Department of Neurology, Stanford University Medical School, CA 94305.
FAU - McKenna, D J
AU  - McKenna DJ
FAU - Peroutka, S J
AU  - Peroutka SJ
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amphetamines)
RN  - 0 (Designer Drugs)
RN  - 0 (Piperidines)
RN  - 333DO1RDJY (Serotonin)
RN  - 41VRH5220H (Paroxetine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 8B1QWR724A (Reserpine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*toxicity
MH  - Amphetamines/*toxicity
MH  - Animals
MH  - Cerebral Cortex/drug effects/metabolism
MH  - Corpus Striatum/drug effects/metabolism
MH  - Designer Drugs/*toxicity
MH  - Dopamine/metabolism
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nerve Endings/metabolism
MH  - Nervous System Diseases/*chemically induced/metabolism/prevention & control
MH  - Paroxetine
MH  - Piperidines/metabolism
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Reserpine/pharmacology/*therapeutic use
MH  - Serotonin/metabolism
EDAT- 1989/09/25 00:00
MHDA- 1989/09/25 00:01
CRDT- 1989/09/25 00:00
PHST- 1989/09/25 00:00 [pubmed]
PHST- 1989/09/25 00:01 [medline]
PHST- 1989/09/25 00:00 [entrez]
AID - 0304-3940(89)90351-0 [pii]
AID - 10.1016/0304-3940(89)90351-0 [doi]
PST - ppublish
SO  - Neurosci Lett. 1989 Sep 25;104(1-2):178-82. doi: 10.1016/0304-3940(89)90351-0.