PMID- 25730461
OWN - NLM
STAT- MEDLINE
DCOM- 20150702
LR  - 20181113
IS  - 0254-5853 (Print)
IS  - 2095-8137 (Electronic)
IS  - 0254-5853 (Linking)
VI  - 36
IP  - 1
DP  - 2015 Jan 18
TI  - Effects of senescence on the expression of BDNF and TrkB receptor in the lateral 
      geniculate nucleus of cats.
PG  - 48-53
LID - 10.13918/j.issn.2095-8137.2015.1.48 [doi]
AB  - To explore the neural mechanisms mediating aging-related visual function 
      declines, we compared the expressions of brain-derived neurotrophic factor (BDNF) 
      and its high affinity receptor-tyrosine kinase B (TrkB) between young and old 
      adult cats. Nissl staining was used to display neurons in each layer of the 
      lateral geniculate nucleus (LGN). The BDNF- and TrkB receptor-immunoreactive 
      neurons were labeled immunohistochemically, observed under optical microscope and 
      photographed. Their neuronal density and immunoreactive intensity were measured. 
      Results showed that the mean density of the Nissl stained neurons in each LGN 
      layer were comparable between old and young adult cats, and their BDNF and TrkB 
      proteins were widely expressed in all LGN layers. However, compared with young 
      adult cats, both the density and optical absorbance intensity of BDNF- and 
      TrkB-immunoreactive cells in each LGN layer in old cats were significantly 
      decreased. These findings indicate that the decreased expressions of BDNF and 
      TrkB proteins in the LGN may be an important factor inducing the compromised 
      inhibition in the central visual nucleus and the functional visual decline in 
      senescent individuals.
FAU - Tong, Chuan-Wang
AU  - Tong CW
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China;College of 
      Biological Engineering, Wuhu Institute of Technology, Wuhu 241000, China.
FAU - Wang, Zi-Lu
AU  - Wang ZL
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China.
FAU - Li, Peng
AU  - Li P
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China.
FAU - Zhu, Hui
AU  - Zhu H
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China.
FAU - Chen, Cui-Yun
AU  - Chen CY
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China.
FAU - Hua, Tian-Miao
AU  - Hua TM
AD  - College of Life Science, Anhui Normal University, Wuhu 241000, China. 
      tmhua@mail.ahnu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Dongwuxue Yanjiu
JT  - Dong wu xue yan jiu = Zoological research
JID - 100961499
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Aging/*physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Cats/*physiology
MH  - Geniculate Bodies/cytology/*metabolism
MH  - Neurons/metabolism
MH  - Receptor, trkB/genetics/*metabolism
PMC - PMC4871216
OTO - NOTNLM
OT  - Age-related change
OT  - BDNF
OT  - Cat
OT  - Lateral geniculate nucleus
OT  - TrkB
COIS- The authors have declared that no competing interests exist.
EDAT- 2015/03/03 06:00
MHDA- 2015/07/03 06:00
PMCR- 2015/01/18
CRDT- 2015/03/03 06:00
PHST- 2015/03/03 06:00 [entrez]
PHST- 2015/03/03 06:00 [pubmed]
PHST- 2015/07/03 06:00 [medline]
PHST- 2015/01/18 00:00 [pmc-release]
AID - ZoolRes-36-1-48 [pii]
AID - 10.13918/j.issn.2095-8137.2015.1.48 [doi]
PST - ppublish
SO  - Dongwuxue Yanjiu. 2015 Jan 18;36(1):48-53. doi: 
      10.13918/j.issn.2095-8137.2015.1.48.