PMID- 2573077
OWN - NLM
STAT- MEDLINE
DCOM- 19891219
LR  - 20190712
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 33
IP  - 2
DP  - 1989 Jun
TI  - The effect of optical isomers of 3,4-methylenedioxymethamphetamine (MDMA) on 
      stereotyped behavior in rats.
PG  - 343-7
AB  - The relative potencies of S(+)-, R(-)-3,4-methylenedioxymethamphetamine (MDMA) 
      and S(+)-methylene-dioxyamphetamine (MDA) in inducing stereotyped behavior were 
      determined in comparison with p-chloroamphetamine. S(+)-MDMA was more potent than 
      R(-)-MDMA in eliciting stereotyped behaviors such as sniffing, head-weaving, 
      backpedalling and turning and wet-dog shakes. These results are consistent with 
      the actions of the drug on release of neurotransmitters in which the S(+) 
      enantiomer is more potent. The desmethyl derivative of (+)MDMA, (+)MDA, was more 
      potent than (+)MDMA in eliciting stereotyped behaviors, and produced wet-dog 
      shake behavior.
FAU - Hiramatsu, M
AU  - Hiramatsu M
AD  - Department of Chemical Pharmacology, Meijo University, Nagoya, Japan.
FAU - Nabeshima, T
AU  - Nabeshima T
FAU - Kameyama, T
AU  - Kameyama T
FAU - Maeda, Y
AU  - Maeda Y
FAU - Cho, A K
AU  - Cho AK
LA  - eng
GR  - DA 04206/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Amphetamines)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 64-12-0 (p-Chloroamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
MH  - Amphetamines/*pharmacology
MH  - Animals
MH  - Behavior, Animal/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Stereoisomerism
MH  - Stereotyped Behavior/*drug effects
MH  - Time Factors
MH  - p-Chloroamphetamine/pharmacology
EDAT- 1989/06/01 00:00
MHDA- 1989/06/01 00:01
CRDT- 1989/06/01 00:00
PHST- 1989/06/01 00:00 [pubmed]
PHST- 1989/06/01 00:01 [medline]
PHST- 1989/06/01 00:00 [entrez]
AID - 0091-3057(89)90511-X [pii]
AID - 10.1016/0091-3057(89)90511-x [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 1989 Jun;33(2):343-7. doi: 10.1016/0091-3057(89)90511-x.