PMID- 25731754
OWN - NLM
STAT- MEDLINE
DCOM- 20160321
LR  - 20191113
IS  - 1874-4745 (Electronic)
IS  - 1874-4737 (Linking)
VI  - 8
IP  - 1
DP  - 2015
TI  - Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.
PG  - 15-25
AB  - Ecstasy or 3,4-methylenedioxymethamphetamine (MDMA) is a popular drug of abuse. 
      In the animal studies MDMA has been shown to have deleterious effects on the 
      serotonergic neurotransmitter system. Understanding the adverse effects of MDMA 
      on human brain function is of considerable importance owing to the rising number 
      of MDMA users. Various neuroimaging studies have investigated the structural, 
      chemical and functional differences in the brain integrity of chronic MDMA users. 
      Various neurocognitive domains like working memory, episodic memory, semantic 
      memory, visual stimulation, motor function and impulsivity have been compared 
      between chronic MDMA users and nonusers using fMRI. The fMRI studies remain much 
      more sensitive in studying the neurological deficits associated with chronic MDMA 
      use as compared to the cognitive studies alone and therefore they serve as a 
      prelude in our understanding of MDMA induced neurotoxicity. However they still 
      face certain limitations contributing to inconsistency in the results and further 
      research is needed before we can draw definitive conclusions regarding the 
      neurotoxic effects of MDMA.
FAU - Garg, Aayushi
AU  - Garg A
FAU - Kapoor, Saloni
AU  - Kapoor S
FAU - Goel, Mishita
AU  - Goel M
FAU - Chopra, Saurav
AU  - Chopra S
FAU - Chopra, Manav
AU  - Chopra M
FAU - Kapoor, Anirudh
AU  - Kapoor A
FAU - McCann, Una D
AU  - McCann UD
FAU - Behera, Chittaranjan
AU  - Behera C
AD  - Department of Forensic medicine, Room No.303, New Forensic Block, AIIMS, New 
      Delhi, India. drchitta75@rediffmail.com.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Abuse Rev
JT  - Current drug abuse reviews
JID - 101468123
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amphetamine-Related Disorders/complications
MH  - Animals
MH  - Brain/drug effects/pathology
MH  - Cognition/drug effects
MH  - Cognition Disorders/chemically induced
MH  - Hallucinogens/*adverse effects
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*adverse effects
MH  - Neurotoxicity Syndromes/diagnosis/etiology
EDAT- 2015/03/04 06:00
MHDA- 2016/03/22 06:00
CRDT- 2015/03/04 06:00
PHST- 2014/12/08 00:00 [received]
PHST- 2015/02/18 00:00 [revised]
PHST- 2015/02/25 00:00 [accepted]
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2016/03/22 06:00 [medline]
AID - CDAR-EPUB-65615 [pii]
AID - 10.2174/1874473708666150303115833 [doi]
PST - ppublish
SO  - Curr Drug Abuse Rev. 2015;8(1):15-25. doi: 10.2174/1874473708666150303115833.