PMID- 25732310
OWN - NLM
STAT- MEDLINE
DCOM- 20151123
LR  - 20150303
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 863
DP  - 2015 Mar 10
TI  - Multi-analyte high performance liquid chromatography coupled to high resolution 
      tandem mass spectrometry method for control of pesticide residues, mycotoxins, 
      and pyrrolizidine alkaloids.
PG  - 29-40
LID - S0003-2670(15)00075-6 [pii]
LID - 10.1016/j.aca.2015.01.021 [doi]
AB  - A new reliable and highly sensitive method based on high performance liquid 
      chromatographic (HPLC) separation and high resolution tandem mass spectrometric 
      detection (HRMS/MS) has been developed and validated for determination of 323 
      pesticide residues, 55 mycotoxins, and 11 plant toxins represented by 
      pyrrolizidine alkaloids. The method was validated for three matrices, leek, 
      wheat, and tea differing in nature/amount of co-extracts that may cause various 
      matrix effects. For target analytes isolation, optimized QuEChERS-based (quick, 
      easy, cheap, effective, rugged, and safe) extraction procedure was employed. 
      Spectral HRMS/MS library has been established providing an entire spectrum of 
      fragment ions for each analyte, which allows unbiased identification and 
      confirmation of target compounds. The limits of quantification (LOQs) of target 
      analytes were below 10 mug kg(-1) for 82%, 81%, and 61% for matrices leek, wheat, 
      and tea, respectively. Recoveries were in the acceptable range (70-120%) 
      according to SANCO/12571/2013 for most of target analytes, except for highly 
      polar 'masked' mycotoxin deoxynivalenol-3-glucoside with recoveries 35%, 47%, and 
      42% for matrices leek, wheat, and tea, respectively. The linearities of 
      calibration curves expressed as coefficients of determination were in the range 
      of 0.9661-1.000, and repeatabilities expressed as relative standard deviations 
      (RSDs) at LOQs lied in the range of 0.25-13.51%. The trueness of the method was 
      verified using several certified reference materials (CRMs) and proficiency test 
      samples.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Dzuman, Zbynek
AU  - Dzuman Z
AD  - University of Chemistry and Technology, Prague, Technicka 3, Prague 6, 16628, 
      Czech Republic.
FAU - Zachariasova, Milena
AU  - Zachariasova M
AD  - University of Chemistry and Technology, Prague, Technicka 3, Prague 6, 16628, 
      Czech Republic. Electronic address: milena.zachariasova@vscht.cz.
FAU - Veprikova, Zdenka
AU  - Veprikova Z
AD  - University of Chemistry and Technology, Prague, Technicka 3, Prague 6, 16628, 
      Czech Republic.
FAU - Godula, Michal
AU  - Godula M
AD  - Thermo Scientific, Slunecna 27, Prague 10, 10000, Czech Republic.
FAU - Hajslova, Jana
AU  - Hajslova J
AD  - University of Chemistry and Technology, Prague, Technicka 3, Prague 6, 16628, 
      Czech Republic.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150123
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Mycotoxins)
RN  - 0 (Pesticide Residues)
RN  - 0 (Pyrrolizidine Alkaloids)
SB  - IM
MH  - Chromatography, High Pressure Liquid/*methods
MH  - Molecular Structure
MH  - Mycotoxins/*analysis
MH  - Pesticide Residues/*analysis
MH  - Pyrrolizidine Alkaloids/*analysis
MH  - Tandem Mass Spectrometry/*methods
OTO - NOTNLM
OT  - High performance liquid chromatography
OT  - High resolution tandem mass spectrometry
OT  - Mycotoxins
OT  - Orbitrap
OT  - Pesticide residues
OT  - Quick easy cheap effective rugged safe
EDAT- 2015/03/04 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/03/04 06:00
PHST- 2014/11/11 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S0003-2670(15)00075-6 [pii]
AID - 10.1016/j.aca.2015.01.021 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2015 Mar 10;863:29-40. doi: 10.1016/j.aca.2015.01.021. Epub 2015 
      Jan 23.