PMID- 25732691
OWN - NLM
STAT- MEDLINE
DCOM- 20151113
LR  - 20210209
IS  - 1873-4324 (Electronic)
IS  - 0003-2670 (Linking)
VI  - 866
DP  - 2015 Mar 25
TI  - Determination of 13 endocrine disrupting chemicals in sediments by gas 
      chromatography-mass spectrometry using subcritical water extraction coupled with 
      dispersed liquid-liquid microextraction and derivatization.
PG  - 41-47
LID - S0003-2670(15)00187-7 [pii]
LID - 10.1016/j.aca.2015.02.011 [doi]
AB  - In this study, a sample pretreatment method was developed for the determination 
      of 13 endocrine disrupting chemicals (EDCs) in sediment samples based on the 
      combination of subcritical water extraction (SWE) and dispersed liquid-liquid 
      microextraction (DLLME). The subcritical water that provided by accelerated 
      solvent extractor (ASE) was the sample solution (water) for the following DLLME 
      and the soluble organic modifier that spiked in the subcritical water was also 
      used as the disperser solvent for DLLME in succession. Thus, several important 
      parameters that affected both SWE and DLLME were investigated, such as the 
      extraction solvent for DLLME (chlorobenzene), extraction time for DLLME (30s), 
      selection of organic modifier for SWE (acetone), volume of organic modifier (10%) 
      and extraction temperature for SWE (150  degrees C). In addition, good chromatographic 
      behavior was achieved for GC-MS after derivatisation by using 
      N,O-bis(trimethylsilyl) trifluoroacetamide (BSTFA). As a result, proposed method 
      sensitive and reliable with the limits of detection (LODs) ranging from 0.006 ng 
      g(-1) (BPA) to 0.639 ng g(-1) (19-norethisterone) and the relative standard 
      deviations (RSDs) between 1.5% (E2) and 15.0% (DES). Moreover, the proposed 
      method was compared with direct ASE extraction that reported previously, and the 
      results showed that SWE-DLLME was more promising with recoveries ranging from 
      42.3% (dienestrol) to 131.3% (4,5alpha-dihydrotestosterone), except for 
      diethylstilbestrol (15.0%) and nonylphenols (29.8%). The proposed method was then 
      successfully applied to determine 13 EDCs sediment of Humen outlet of the Pearl 
      River, 12 of target compounds could be detected, and 10 could be quantitative 
      analysis with the total concentration being 39.6 ng g(-1), and which indicated 
      that the sediment of Humen outlet was heavily contaminated by EDCs.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Yuan, Ke
AU  - Yuan K
AD  - MOE Key Laboratory of Aquatic Product Safety, School of Life Sciences, Sun 
      Yat-Sen University, Guangzhou 510275, PR China.
FAU - Kang, Haining
AU  - Kang H
AD  - Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, PR China.
FAU - Yue, Zhenfeng
AU  - Yue Z
AD  - Shenzhen Entry-Exit Inspection and Quarantine Bureau, Shenzhen 518045, PR China.
FAU - Yang, Lihua
AU  - Yang L
AD  - Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, 
      School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China.
FAU - Lin, Li
AU  - Lin L
AD  - MOE Key Laboratory of Aquatic Product Safety, School of Life Sciences, Sun 
      Yat-Sen University, Guangzhou 510275, PR China.
FAU - Wang, Xiaowei
AU  - Wang X
AD  - Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, 
      School of Marine Sciences, Sun Yat-Sen University, Guangzhou 510275, PR China. 
      Electronic address: wangxw5@mail.sysu.edu.cn.
FAU - Luan, Tiangang
AU  - Luan T
AD  - MOE Key Laboratory of Aquatic Product Safety, School of Life Sciences, Sun 
      Yat-Sen University, Guangzhou 510275, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150210
PL  - Netherlands
TA  - Anal Chim Acta
JT  - Analytica chimica acta
JID - 0370534
RN  - 0 (Acetamides)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (N,O-bis(trimethylsilyl)trifluoroacetamide)
RN  - 0 (Trimethylsilyl Compounds)
RN  - 059QF0KO0R (Water)
SB  - IM
MH  - Acetamides/chemistry
MH  - Endocrine Disruptors/*analysis/chemistry/isolation & purification
MH  - *Gas Chromatography-Mass Spectrometry
MH  - Geologic Sediments/*chemistry
MH  - Liquid Phase Microextraction
MH  - Temperature
MH  - Trimethylsilyl Compounds/chemistry
MH  - Water/chemistry
OTO - NOTNLM
OT  - Derivatization
OT  - Dispersed liquid-liquid extraction
OT  - Endocrine disrupting chemicals
OT  - Sediment
OT  - Subcritical water extraction
EDAT- 2015/03/04 06:00
MHDA- 2015/11/14 06:00
CRDT- 2015/03/04 06:00
PHST- 2014/10/03 00:00 [received]
PHST- 2015/01/29 00:00 [revised]
PHST- 2015/02/08 00:00 [accepted]
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2015/11/14 06:00 [medline]
AID - S0003-2670(15)00187-7 [pii]
AID - 10.1016/j.aca.2015.02.011 [doi]
PST - ppublish
SO  - Anal Chim Acta. 2015 Mar 25;866:41-47. doi: 10.1016/j.aca.2015.02.011. Epub 2015 
      Feb 10.