PMID- 2573306
OWN - NLM
STAT- MEDLINE
DCOM- 19891220
LR  - 20220331
IS  - 0003-4819 (Print)
IS  - 0003-4819 (Linking)
VI  - 111
IP  - 11
DP  - 1989 Dec 1
TI  - Human T-cell lymphotropic virus type I (HTLV-I)-associated adult T-cell 
      leukemia-lymphoma in a patient infected with human immunodeficiency virus type 1 
      (HIV-1).
PG  - 871-5
AB  - A patient had adult T-cell leukemia-lymphoma in the unusual setting of 
      coinfection with human immunodeficiency virus type 1 (HIV-1) and human T-cell 
      lymphotropic virus type I (HTLV-I). The leukemic cells were CD4 positive and 
      showed clonal genetic rearrangement of the T-cell receptor complex. Cytogenetic 
      analysis showed three clonal karyotypic abnormalities: trisomy 3 and two 
      translocations [t(1;15), (X;1)]. The patient was seropositive for HIV and HTLV-I; 
      HTLV-I and HIV-1 DNA sequences were detected in peripheral blood leukocytes by 
      the polymerase chain reaction. The HTLV-I sequences were detected in a relatively 
      high proportion of mononuclear cells (at least 1 in 30 cells), whereas HIV-1 
      sequences were detected in a smaller proportion of cells (at least 1 in 3000 
      cells). Clinical remission was achieved after chemotherapy. There was a decrease 
      in the proportion of HTLV-I positive mononuclear cells (at least 1 in 1000 
      cells), whereas the proportion of HIV-1 positive cells was relatively unchanged 
      (at least 1 in 1000 cells). Adult T-cell leukemia-lymphoma in the setting of HIV 
      coinfection may become increasingly common because asymptomatic retroviral 
      coinfections are frequent.
FAU - Shibata, D
AU  - Shibata D
AD  - University of Southern California School of Medicine, Los Angeles.
FAU - Brynes, R K
AU  - Brynes RK
FAU - Rabinowitz, A
AU  - Rabinowitz A
FAU - Hanson, C A
AU  - Hanson CA
FAU - Slovak, M L
AU  - Slovak ML
FAU - Spira, T J
AU  - Spira TJ
FAU - Gill, P
AU  - Gill P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Ann Intern Med
JT  - Annals of internal medicine
JID - 0372351
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Adult
MH  - CD4-Positive T-Lymphocytes
MH  - DNA, Viral/analysis
MH  - Gene Rearrangement, T-Lymphocyte
MH  - HIV Infections/*complications/genetics
MH  - *HIV-1/genetics/isolation & purification
MH  - Human T-lymphotropic virus 1/genetics/isolation & purification
MH  - Humans
MH  - Karyotyping
MH  - Leukemia-Lymphoma, Adult T-Cell/*complications/genetics
MH  - Leukocyte Count
MH  - Male
MH  - Polymerase Chain Reaction
MH  - T-Lymphocytes, Regulatory
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
AID - 10.7326/0003-4819-111-11-871 [doi]
PST - ppublish
SO  - Ann Intern Med. 1989 Dec 1;111(11):871-5. doi: 10.7326/0003-4819-111-11-871.