PMID- 25733319
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20220409
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 22
IP  - 4
DP  - 2015
TI  - White blood cell count to mean platelet volume ratio as a novel non-invasive 
      marker predicting long-term outcomes in patients with non-ST elevation acute 
      coronary syndrome.
PG  - 437-45
LID - 10.5603/CJ.a2015.0015 [doi]
AB  - BACKGROUND: Total white blood cell (WBC) count and mean platelet volume have 
      previously been shown to predict outcomes in acute coronary syndrome (ACS) 
      patients. In this prospective study, we sought to determine the prognostic value 
      of baseline WBC count to mean platelet volume ratio (WMR) in patients with non-ST 
      elevation acute coronary syndrome (NSTE-ACS). METHODS: A total of 490 patients 
      with NSTE-ACS were prospectively enrolled. The relationship between baseline WMR 
      and major adverse cardiovascular events (MACE) incidence was assessed during a 
      mean follow-up of 330.8 +/- 38 days. RESULTS: The patients' mean age was 60.4 +/- 
      12.9 year, 59% of them were male. The patients were categorized into two groups 
      based on WMR values, high- and low-WMR groups (< 755 vs. >/= 755). The incidence of 
      MACE was significantly higher in high-WMR compared with that of low-WMR group 
      (22.4% vs. 10.7%, p < 0.001). Total WBC counts (median 7.9 vs. 6.9 x103/muL, p = 
      0.004), neutrophil count (median 4.6 vs. 4.2 x103/muL, p = 0.021), and WMR (median 
      863.2 vs. 731.5, p = 0.001) were significantly higher in the MACE-positive than 
      MACE-negative group. The high-WMR was found to be significantly associated with 
      the MACE-free survival rate (p < 0.001). In an adjusted cox regression model, the 
      elevated WMR was independently predicted the incidence of MACE (hazard ratio 
      2.419, 95% CI 1.515-3.862, p < 0.001). CONCLUSIONS: The elevated baseline WMR 
      independently predicted the MACE incidence in patients with NSTE-ACS during 
      long-term follow-up.
FAU - Dehghani, Mohammad Reza
AU  - Dehghani MR
FAU - Rezaei, Yousef
AU  - Rezaei Y
AD  - Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences, Urmia, 
      Iran. yousefrezaei1986@gmail.com.
FAU - Taghipour-Sani, Leila
AU  - Taghipour-Sani L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20150303
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
SB  - IM
CIN - Cardiol J. 2015;22(3):351-2. PMID: 26119813
CIN - Cardiol J. 2015;22(3):353-4. PMID: 26120080
MH  - Acute Coronary Syndrome/*blood/diagnosis/epidemiology
MH  - Aged
MH  - *Blood Platelets
MH  - Chi-Square Distribution
MH  - Disease Progression
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Iran/epidemiology
MH  - Kaplan-Meier Estimate
MH  - Leukocyte Count
MH  - *Leukocytes
MH  - Male
MH  - Mean Platelet Volume
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Risk Assessment
MH  - Risk Factors
MH  - Time Factors
EDAT- 2015/03/04 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/03/04 06:00
PHST- 2014/12/15 00:00 [received]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/02/25 00:00 [revised]
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - VM/OJS/J/40487 [pii]
AID - 10.5603/CJ.a2015.0015 [doi]
PST - ppublish
SO  - Cardiol J. 2015;22(4):437-45. doi: 10.5603/CJ.a2015.0015. Epub 2015 Mar 3.