PMID- 25733460
OWN - NLM
STAT- MEDLINE
DCOM- 20150427
LR  - 20230216
IS  - 1541-6100 (Electronic)
IS  - 0022-3166 (Linking)
VI  - 145
IP  - 3
DP  - 2015 Mar
TI  - Sugar-sweetened product consumption alters glucose homeostasis compared with 
      dairy product consumption in men and women at risk of type 2 diabetes mellitus.
PG  - 459-66
LID - 10.3945/jn.114.204503 [doi]
AB  - BACKGROUND: Dietary patterns characterized by high intakes of fruits and 
      vegetables, whole grains, low-fat dairy products, and low glycemic load have been 
      associated with lower type 2 diabetes mellitus (T2DM) risk. In contrast, dietary 
      patterns that include high intakes of refined grains, processed meats, and high 
      amounts of added sugars have been associated with increased T2DM risk. OBJECTIVE: 
      This randomized, 2-period crossover trial compared the effects of dairy and 
      sugar-sweetened product (SSP) consumption on insulin sensitivity and pancreatic 
      beta-cell function in men and women at risk of the development of T2DM who 
      habitually consume sugar-sweetened beverages. METHODS: In a randomized, 
      controlled crossover trial, participants consumed dairy products (474 mL/d 2% 
      milk and 170 g/d low-fat yogurt) and SSPs (710 mL/d nondiet soda and 108 g/d 
      nondairy pudding), each for 6 wk, with a 2-wk washout between treatments. A 
      liquid meal tolerance test (LMTT) was administered at baseline and the end of 
      each period. RESULTS: Participants were 50% female with a mean age and body mass 
      index of 53.8 y and 32.2 kg/m(2), respectively. Changes from baseline were 
      significantly different between dairy product and SSP conditions for median 
      homeostasis model assessment 2-insulin sensitivity (HOMA2-%S) (1.3 vs. -21.3%, 
      respectively, P = 0.009; baseline = 118%), mean LMTT disposition index (-0.03 vs. 
      -0.36, respectively, P = 0.011; baseline = 2.59), mean HDL cholesterol (0.8 vs. 
      -4.2%, respectively, P = 0.015; baseline = 44.3 mg/dL), and mean serum 
      25-hydroxyvitamin D [25(OH)D] (11.7 vs. -3.3, respectively, P = 0.022; baseline = 
      24.5 mug/L). Changes from baseline in LMTT Matsuda insulin sensitivity index 
      (-0.10 vs. -0.49, respectively; baseline = 4.16) and mean HOMA2-beta-cell function 
      (-2.0 vs. 5.3%, respectively; baseline = 72.6%) did not differ significantly 
      between treatments. CONCLUSION: These results suggest that SSP consumption is 
      associated with less favorable values for HOMA2-%S, LMTT disposition index, HDL 
      cholesterol, and serum 25(OH)D in men and women at risk of T2DM vs. baseline 
      values and values during dairy product consumption. This trial was registered at 
      clinicaltrials.gov as NCT01936935.
CI  - (c) 2015 American Society for Nutrition.
FAU - Maki, Kevin C
AU  - Maki KC
AD  - Biofortis Clinical Research, Addison, IL; and Midwest Center for Metabolic and 
      Cardiovascular Research, Glen Ellyn, IL kmaki@mc-mcr.com.
FAU - Nieman, Kristin M
AU  - Nieman KM
AD  - Biofortis Clinical Research, Addison, IL; and.
FAU - Schild, Arianne L
AU  - Schild AL
AD  - Biofortis Clinical Research, Addison, IL; and.
FAU - Kaden, Valerie N
AU  - Kaden VN
AD  - Biofortis Clinical Research, Addison, IL; and.
FAU - Lawless, Andrea L
AU  - Lawless AL
AD  - Biofortis Clinical Research, Addison, IL; and.
FAU - Kelley, Kathleen M
AU  - Kelley KM
AD  - Biofortis Clinical Research, Addison, IL; and.
FAU - Rains, Tia M
AU  - Rains TM
AD  - Biofortis Clinical Research, Addison, IL; and.
LA  - eng
SI  - ClinicalTrials.gov/NCT01936935
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150107
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Blood Glucose)
RN  - 0 (Cholesterol, HDL)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Dietary Sucrose)
RN  - 0 (Insulin)
RN  - 0 (Nutritive Sweeteners)
RN  - 0 (Triglycerides)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Cholesterol, HDL/blood
MH  - Cholesterol, LDL/blood
MH  - Cross-Over Studies
MH  - Dairy Products
MH  - Diabetes Mellitus, Type 2/blood/diet therapy/*prevention & control
MH  - Dietary Sucrose/*administration & dosage
MH  - *Feeding Behavior
MH  - Female
MH  - *Homeostasis
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance
MH  - Insulin-Secreting Cells/metabolism
MH  - Male
MH  - Middle Aged
MH  - Nutritive Sweeteners/administration & dosage
MH  - Risk Factors
MH  - Triglycerides/blood
MH  - Vitamin D/blood
OTO - NOTNLM
OT  - Insulin sensitivity
OT  - dairy
OT  - lipoproteins
OT  - sugars
OT  - type 2 diabetes mellitus
EDAT- 2015/03/04 06:00
MHDA- 2015/04/29 06:00
CRDT- 2015/03/04 06:00
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2015/04/29 06:00 [medline]
AID - S0022-3166(22)08647-3 [pii]
AID - 10.3945/jn.114.204503 [doi]
PST - ppublish
SO  - J Nutr. 2015 Mar;145(3):459-66. doi: 10.3945/jn.114.204503. Epub 2015 Jan 7.