PMID- 25734326 OWN - NLM STAT- MEDLINE DCOM- 20160129 LR - 20200306 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 3 DP - 2015 TI - Plasma concentrations of BDNF and IGF-1 in abstinent cocaine users with high prevalence of substance use disorders: relationship to psychiatric comorbidity. PG - e0118610 LID - 10.1371/journal.pone.0118610 [doi] LID - e0118610 AB - Recent studies have identified biomarkers related to the severity and pathogenesis of cocaine addiction and common comorbid psychiatric disorders. Monitoring these plasma mediators may improve the stratification of cocaine users seeking treatment. Because the neurotrophic factors are involved in neural plasticity, neurogenesis and neuronal survival, we have determined plasma concentrations of brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1) and IGF-1 binding protein 3 (IGFBP-3) in a cross-sectional study with abstinent cocaine users who sought outpatient treatment for cocaine (n = 100) and age/body mass matched controls (n = 85). Participants were assessed with the diagnostic interview 'Psychiatric Research Interview for Substance and Mental Disorders'. Plasma concentrations of these peptides were not different in cocaine users and controls. They were not associated with length of abstinence, duration of cocaine use or cocaine symptom severity. The pathological use of cocaine did not influence the association of IGF-1 with age observed in healthy subjects, but the correlation between IGF-1 and IGFBP-3 was not significantly detected. Correlation analyses were performed between these peptides and other molecules sensitive to addiction: BDNF concentrations were not associated with inflammatory mediators, lipid derivatives or IGF-1 in cocaine users, but correlated with chemokines (fractalkine/CX3CL1 and SDF-1/CXCL12) and N-acyl-ethanolamines (N-palmitoyl-, N-oleoyl-, N-arachidonoyl-, N-linoleoyl- and N-dihomo-gamma-linolenoyl-ethanolamine) in controls; IGF-1 concentrations only showed association with IGFBP-3 concentrations in controls; and IGFBP-3 was only correlated with N-stearoyl-ethanolamine concentrations in cocaine users. Multiple substance use disorders and life-time comorbid psychopathologies were common in abstinent cocaine users. Interestingly, plasma BDNF concentrations were exclusively found to be decreased in users diagnosed with both primary and cocaine-induced disorders for mood and anxiety disorders. In summary, BDNF, IGF-1 and IGFBP-3 were not affected by a history of pathological use of cocaine supported by the absence of associations with other molecules sensitive to cocaine addiction. However, BDNF was affected by comorbid mood disorders. Further research is necessary to elucidate the role of BDNF and IGF-1 in the transition to cocaine addiction and associated psychiatric comorbidity. FAU - Pedraz, Maria AU - Pedraz M AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Martin-Velasco, Ana Isabel AU - Martin-Velasco AI AD - Department of Physiology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. FAU - Garcia-Marchena, Nuria AU - Garcia-Marchena N AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Araos, Pedro AU - Araos P AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Serrano, Antonia AU - Serrano A AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Romero-Sanchiz, Pablo AU - Romero-Sanchiz P AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Suarez, Juan AU - Suarez J AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Castilla-Ortega, Estela AU - Castilla-Ortega E AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. FAU - Barrios, Vicente AU - Barrios V AD - Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Nino Jesus, Instituto de Investigacion La Princesa, Madrid, Spain; Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Campos-Cloute, Rafael AU - Campos-Cloute R AD - Centro de Tratamiento Ambulatorio Mijas Costa-Diputacion de Malaga, Mijas, Spain. FAU - Ruiz, Juan Jesus AU - Ruiz JJ AD - Centro Provincial de Drogodependencia-Diputacion de Malaga, Malaga, Spain. FAU - Torrens, Marta AU - Torrens M AD - Neurosciences Program, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain; Institut de Neuropsiquiatria i Addiccions (INAD) del Parc de Salut MAR, Barcelona, Spain; Department of Psychiatry. Universitat Autonoma de Barcelona (UAB), Barcelona, Spain. FAU - Chowen, Julie Ann AU - Chowen JA AD - Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Nino Jesus, Instituto de Investigacion La Princesa, Madrid, Spain; Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Argente, Jesus AU - Argente J AD - Department of Pediatrics & Pediatric Endocrinology, Hospital Infantil Universitario Nino Jesus, Instituto de Investigacion La Princesa, Madrid, Spain; Department of Pediatrics, Universidad Autonoma de Madrid, Madrid, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - de la Torre, Rafael AU - de la Torre R AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Neurosciences Program, Institut Hospital del Mar d'Investigacions Mediques (IMIM), Barcelona, Spain; Facultat de Ciencies de la Salut i de la Vida, Universitat Pompeu Fabra (CEXS-UPF), Barcelona, Spain. FAU - Santin, Luis Javier AU - Santin LJ AD - Departamento de Psicobiologia y Metodologia de las Ciencias del Comportamiento, Facultad de Psicologia, Universidad de Malaga, Malaga, Spain. FAU - Villanua, Maria Angeles AU - Villanua MA AD - Department of Physiology, Faculty of Medicine, Complutense University of Madrid, Madrid, Spain. FAU - Rodriguez de Fonseca, Fernando AU - Rodriguez de Fonseca F AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain; Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Pavon, Francisco Javier AU - Pavon FJ AD - Unidad Gestion Clinica de Salud Mental, Instituto de Investigacion Biomedica de Malaga (IBIMA), Hospital Regional Universitario de Malaga-Universidad de Malaga, Malaga, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150303 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Chemokines) RN - 0 (Cytokines) RN - 0 (IGFBP3 protein, human) RN - 0 (Insulin-Like Growth Factor Binding Protein 3) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Brain-Derived Neurotrophic Factor/*blood MH - Chemokines/blood MH - Cocaine-Related Disorders/complications/*diagnosis/epidemiology MH - Cross-Sectional Studies MH - Cytokines/blood MH - Female MH - Humans MH - Immunoassay MH - Insulin-Like Growth Factor Binding Protein 3/blood MH - Insulin-Like Growth Factor I/*analysis MH - Interviews as Topic MH - Male MH - Mental Disorders/complications/diagnosis MH - Middle Aged MH - Prevalence MH - Radioimmunoassay MH - Young Adult PMC - PMC4348520 COIS- Competing Interests: Rafael de la Torre is a Plos ONE Editorial Board member, but this does not alter the authors' adherence to PLOS ONE Editorial policies and criteria. The other authors declare no conflicts of interest. EDAT- 2015/03/04 06:00 MHDA- 2016/01/30 06:00 PMCR- 2015/03/03 CRDT- 2015/03/04 06:00 PHST- 2014/10/03 00:00 [received] PHST- 2015/01/19 00:00 [accepted] PHST- 2015/03/04 06:00 [entrez] PHST- 2015/03/04 06:00 [pubmed] PHST- 2016/01/30 06:00 [medline] PHST- 2015/03/03 00:00 [pmc-release] AID - PONE-D-14-44568 [pii] AID - 10.1371/journal.pone.0118610 [doi] PST - epublish SO - PLoS One. 2015 Mar 3;10(3):e0118610. doi: 10.1371/journal.pone.0118610. eCollection 2015.