PMID- 25734485
OWN - NLM
STAT- MEDLINE
DCOM- 20160114
LR  - 20220330
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 3
DP  - 2015
TI  - Invitation cards during pregnancy enhance male partner involvement in prevention 
      of mother to child transmission (PMTCT) of human immunodeficiency virus (HIV) in 
      Blantyre, Malawi: a randomized controlled open label trial.
PG  - e0119273
LID - 10.1371/journal.pone.0119273 [doi]
LID - e0119273
AB  - INTRODUCTION: Male involvement (MI) is vital for the uptake of Prevention of 
      Mother to Child Transmission (PMTCT) of Human Immunodeficiency Virus (HIV) 
      interventions. Partner notification (PN) is among the strategies identified for 
      MI in PMTCT services. The purpose of this randomized controlled trial was to 
      evaluate the efficacy of an invitation card to the male partners as a strategy 
      for MI in PMTCT services by comparing the proportion of pregnant women that were 
      accompanied by their partners between the intervention and the non-intervention 
      study groups. METHODS: Pregnant women attending antenatal care without a male 
      partner at South Lunzu and Mpemba health centres in Blantyre, Malawi, were 
      enrolled in the study from June to December 2013. In an intention-to-treat 
      analysis, we compared all participants that were randomized in the invitation 
      card group with the standard of care (SoC) group. Risk ratios (RR) with 95% 
      confidence intervals (CI) were computed to assess the efficacy of the invitation 
      card. RESULTS: Of the 462 randomized women, 65/230 (28.26%) of the women in the 
      invitation card group reported to the antenatal care clinic with their partners 
      compared to 44/232 (18.97%) women in the SoC group. In an unadjusted 
      intention-to-treat analysis women in the invitation card group were 50% more 
      likely to be accompanied by their male partners than those in the SoC group RR: 
      1.49 (95% CI: 1.06-2.09); p = 0.02. Our random effects analysis showed that there 
      was no clustering by site of recruitment with an inter cluster correlation 
      coefficient (ICC) of 1.98 x 10(-3), (95% CI: 1.78 x10(-7) - 0.96 x 10(-1)); p 
      =0.403. CONCLUSION: An invitation card significantly increased the proportion of 
      women who were accompanied by their male partners for the PMTCT services. An 
      invitation card is a feasible strategy for MI in PMTCT.
FAU - Nyondo, Alinane Linda
AU  - Nyondo AL
AD  - School of Public Health and Family Medicine, College of Medicine, University of 
      Malawi, Blantyre, Malawi.
FAU - Choko, Augustine Talumba
AU  - Choko AT
AD  - Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
FAU - Chimwaza, Angela Faith
AU  - Chimwaza AF
AD  - Kamuzu College of Nursing, University of Malawi, Blantyre, Malawi.
FAU - Muula, Adamson Sinjani
AU  - Muula AS
AD  - School of Public Health and Family Medicine, College of Medicine, University of 
      Malawi, Blantyre, Malawi.
LA  - eng
GR  - WT_/Wellcome Trust/United Kingdom
GR  - 087547/Z/08/Z/WT_/Wellcome Trust/United Kingdom
GR  - HRCSI/PhD/12/09/WT_/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adult
MH  - Female
MH  - HIV/physiology
MH  - HIV Infections/*prevention & control
MH  - *Health Knowledge, Attitudes, Practice
MH  - Humans
MH  - Infectious Disease Transmission, Vertical/*prevention & control
MH  - Malawi
MH  - Male
MH  - Mothers/psychology
MH  - Patient Acceptance of Health Care/psychology/*statistics & numerical data
MH  - Pregnancy
MH  - Prenatal Care/*methods
MH  - Sexual Partners/psychology
MH  - Spouses/psychology
PMC - PMC4348422
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/03/04 06:00
MHDA- 2016/01/15 06:00
PMCR- 2015/03/03
CRDT- 2015/03/04 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2015/01/12 00:00 [accepted]
PHST- 2015/03/04 06:00 [entrez]
PHST- 2015/03/04 06:00 [pubmed]
PHST- 2016/01/15 06:00 [medline]
PHST- 2015/03/03 00:00 [pmc-release]
AID - PONE-D-14-42950 [pii]
AID - 10.1371/journal.pone.0119273 [doi]
PST - epublish
SO  - PLoS One. 2015 Mar 3;10(3):e0119273. doi: 10.1371/journal.pone.0119273. 
      eCollection 2015.