PMID- 25735090
OWN - NLM
STAT- MEDLINE
DCOM- 20150604
LR  - 20190221
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 28
IP  - 21
DP  - 2014 Nov
TI  - [Expression and significance of DNA-dependent protein kinase in human laryngeal 
      squamous cell carcinoma].
PG  - 1641-4
AB  - OBJECTIVE: To study the expression of DNA-dependent protein kinase (DNA-PK) in 
      human laryngeal squamous cell carcinoma (LSCC) and normal laryngeal mucosa (NLM), 
      and to analysize the relationship between the expression and the 
      clinicopathologic parameters of LSCC. METHOD: Immunohistochemical technique 
      (Envision) was used to detect the expression of DNA-PK in 64 cases of LSCC and 15 
      cases of NLM. To investigate an investigation was conducted on the relationship 
      between the expression and clinico-pathological features of LSCC. RESULT: DNA-PK 
      was lowly expressed in NLM and highly expressed in LSCC,the positive rate of 
      DNA-PK expression was 26.67% (4/15), 78.13% (50/64), respectively, and there was 
      significant different difference between the two groups (P < 0.05). Its 
      expression was correlated with the level of histodifferentiation (P < 0.05), but 
      not with TNM stages and neck lymph node metastasis (P > 0.05). CONCLUSION: DNA-PK 
      may be involved in disease development of LSCC.
FAU - Sun, Jiansong
AU  - Sun J
FAU - Yang, Xiuhai
AU  - Yang X
FAU - Ji, Hongpei
AU  - Ji H
FAU - Zhao, Rui
AU  - Zhao R
FAU - Dai, Yubing
AU  - Dai Y
LA  - chi
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.7.11.1 (DNA-Activated Protein Kinase)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*enzymology/pathology
MH  - DNA-Activated Protein Kinase/*metabolism
MH  - Female
MH  - Head and Neck Neoplasms/*enzymology/pathology
MH  - Humans
MH  - Laryngeal Mucosa/enzymology
MH  - Laryngeal Neoplasms/*enzymology/pathology
MH  - Larynx/*enzymology
MH  - Lymph Nodes
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2015/03/05 06:00
MHDA- 2015/06/05 06:00
CRDT- 2015/03/05 06:00
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2015/06/05 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2014 Nov;28(21):1641-4.