PMID- 25736456
OWN - NLM
STAT- MEDLINE
DCOM- 20160818
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Print)
IS  - 1933-0219 (Linking)
VI  - 8
IP  - 6
DP  - 2015 Nov
TI  - Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and 
      allergic airway disease.
PG  - 1201-11
LID - 10.1038/mi.2015.11 [doi]
AB  - Asthma is a complex airway allergic disease involving the interplay of various 
      cell types, cytokines, and transcriptional factors. Though many factors 
      contribute to disease etiology, the molecular control of disease phenotype and 
      responsiveness is not well understood. Here we report an essential role of the 
      matrix attachment region (MAR)-binding protein SMAR1 in regulating immune 
      response during allergic airway disease. Conditional knockout of SMAR1 in T cells 
      rendered the mice resistant to eosinophilic airway inflammation against ovalbumin 
      (OVA) allergen with low immunoglobulin E (IgE) and interleukin-5 (IL-5) levels. 
      Moreover, a lower IgE/IgG2a ratio and higher interferon-gamma (IFN-gamma) response 
      suggested aberrant skewing of T-cell differentiation toward type 1 helper T cell 
      (Th1) response. We show that SMAR1 functions as a negative regulator of Th1 and 
      Th17 differentiation by interacting with two potential and similar MAR regions 
      present on the promoters of T-bet and IL-17. Thus, we present SMAR1 as a 
      regulator of T-cell differentiation that favors the establishment of Th2 cells by 
      modulating Th1 and Th17 responses.
FAU - Chemmannur, S V
AU  - Chemmannur SV
AD  - National Centre for Cell Science, Pune University, Pune, India.
FAU - Badhwar, A J
AU  - Badhwar AJ
AD  - National Centre for Cell Science, Pune University, Pune, India.
AD  - Piramal Enterprises, Nirlon Complex, Mumbai, India.
FAU - Mirlekar, B
AU  - Mirlekar B
AD  - National Centre for Cell Science, Pune University, Pune, India.
FAU - Malonia, S K
AU  - Malonia SK
AD  - National Centre for Cell Science, Pune University, Pune, India.
AD  - University of Massachusetts Medical School, Worcester, Massachusetts, USA.
FAU - Gupta, M
AU  - Gupta M
AD  - National Centre for Cell Science, Pune University, Pune, India.
FAU - Wadhwa, N
AU  - Wadhwa N
AD  - National Institute of Immunology, New Delhi, India.
FAU - Bopanna, R
AU  - Bopanna R
AD  - National Centre for Cell Science, Pune University, Pune, India.
FAU - Mabalirajan, U
AU  - Mabalirajan U
AD  - CSIR-Institute of Genomic and Integrative Biology, New Delhi, India.
FAU - Majumdar, S
AU  - Majumdar S
AD  - National Institute of Immunology, New Delhi, India.
FAU - Ghosh, B
AU  - Ghosh B
AD  - CSIR-Institute of Genomic and Integrative Biology, New Delhi, India.
FAU - Chattopadhyay, S
AU  - Chattopadhyay S
AD  - National Centre for Cell Science, Pune University, Pune, India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150304
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Banp protein, mouse)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
SB  - IM
CIN - Mucosal Immunol. 2015 Nov;8(6):1181-3. PMID: 26220164
MH  - Animals
MH  - Asthma/*immunology
MH  - Blotting, Western
MH  - Cell Cycle Proteins/*immunology
MH  - Cell Differentiation/*immunology
MH  - Chromatin Immunoprecipitation
MH  - DNA-Binding Proteins/*immunology
MH  - Disease Models, Animal
MH  - Electrophoretic Mobility Shift Assay
MH  - Flow Cytometry
MH  - Fluorescent Antibody Technique
MH  - Hypersensitivity/*immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nuclear Proteins/*immunology
MH  - Real-Time Polymerase Chain Reaction
MH  - T-Lymphocytes, Helper-Inducer/cytology/*immunology
PMC - PMC4762901
EDAT- 2015/03/05 06:00
MHDA- 2016/08/19 06:00
PMCR- 2016/02/23
CRDT- 2015/03/05 06:00
PHST- 2014/11/28 00:00 [received]
PHST- 2015/01/18 00:00 [accepted]
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2016/08/19 06:00 [medline]
PHST- 2016/02/23 00:00 [pmc-release]
AID - S1933-0219(22)01000-5 [pii]
AID - 10.1038/mi.2015.11 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2015 Nov;8(6):1201-11. doi: 10.1038/mi.2015.11. Epub 2015 Mar 4.