PMID- 25736790
OWN - NLM
STAT- MEDLINE
DCOM- 20150825
LR  - 20150330
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 56
IP  - 3
DP  - 2015 Mar 3
TI  - Impact of reticular pseudodrusen on microperimetry and multifocal 
      electroretinography in intermediate age-related macular degeneration.
PG  - 2100-6
LID - 10.1167/iovs.14-16210 [doi]
AB  - PURPOSE: To examine the influence of reticular pseudodrusen (RPD) on retinal and 
      visual function in intermediate AMD using multifocal electroretinography (mfERG) 
      and microperimetry. METHODS: In a prospective cross-sectional study, 
      microperimetry and mfERG testing, followed by color fundus photography, 
      near-infrared reflectance imaging and spectral-domain optical coherence 
      tomography (SD-OCT) scans were performed in 120 eyes from 60 participants with 
      bilateral intermediate AMD. The number of subfields with pigmentary changes and 
      RPD within the central 3-mm diameter of the Early Treatment of Diabetic 
      Retinopathy Study (ETDRS) grid and drusen cube root volume within the central 
      3-mm diameter was determined. The influence of these pathological features on 
      microperimetry and mfERG in this region were examined. RESULTS: Microperimetric 
      sensitivity was not significantly associated with the presence and extent of RPD 
      (P = 0.068), but with drusen volume and extent of pigmentary changes (P < 0.001 
      for both). However, the presence and extent of RPD was independently and 
      significantly associated with mfERG implicit time, along with drusen volume and 
      the extent of pigmentary changes (P </= 0.023). The mfERG response amplitude was 
      not significantly associated with the presence and extent of RPD (P = 0.130). 
      CONCLUSIONS: The presence and extent of RPD was associated with functional 
      changes on mfERG implicit time, but not mfERG response amplitude or 
      microperimetry. These findings suggest that the presence of RPD in eyes with 
      intermediate AMD has a significant influence on cone-mediated neuroretinal 
      function, without a significant influence on mesopic visual function as 
      determined on microperimetry.
CI  - Copyright 2015 The Association for Research in Vision and Ophthalmology, Inc.
FAU - Wu, Zhichao
AU  - Wu Z
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Ayton, Lauren N
AU  - Ayton LN
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Makeyeva, Galina
AU  - Makeyeva G
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Guymer, Robyn H
AU  - Guymer RH
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
FAU - Luu, Chi D
AU  - Luu CD
AD  - Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye 
      and Ear Hospital, Victoria, Australia.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Electroretinography/methods
MH  - Female
MH  - Humans
MH  - Macular Degeneration/*pathology/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Retinal Drusen/*pathology/*physiopathology
MH  - Visual Field Tests/methods
MH  - Visual Fields/physiology
OTO - NOTNLM
OT  - AMD
OT  - microperimetry
OT  - multifocal electroretinography
OT  - spectral-domain optical coherence tomography
EDAT- 2015/03/05 06:00
MHDA- 2015/08/26 06:00
CRDT- 2015/03/05 06:00
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2015/08/26 06:00 [medline]
AID - iovs.14-16210 [pii]
AID - 10.1167/iovs.14-16210 [doi]
PST - epublish
SO  - Invest Ophthalmol Vis Sci. 2015 Mar 3;56(3):2100-6. doi: 10.1167/iovs.14-16210.