PMID- 25737197
OWN - NLM
STAT- MEDLINE
DCOM- 20160216
LR  - 20220726
IS  - 1878-1705 (Electronic)
IS  - 1567-5769 (Linking)
VI  - 26
IP  - 1
DP  - 2015 May
TI  - 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose increases a population of T 
      regulatory cells and inhibits IgE production in ovalbumin-sensitized mice.
PG  - 30-6
LID - S1567-5769(15)00072-7 [pii]
LID - 10.1016/j.intimp.2015.02.025 [doi]
AB  - 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose (PGG) is a gallotannin isolated from 
      various plants. In a previous study, it was reported that PGG suppressed 
      interleukin (IL)-4 induced signal pathway in B cell which is indispensable for 
      immunoglobulin E (IgE) production. However, the suppressive effect of PGG on IgE 
      production in allergen-sensitized mice remains unclear. Therefore, the aim of 
      this study was to investigate the inhibitory effect of PGG on IgE production in 
      ovalbumin (OVA)-sensitized mice. Mice orally administered PGG showed a decrease 
      in total and OVA-specific IgE levels in serum. Oral administration of PGG 
      strongly suppressed production of type 2 T helper (IL-4 and IL-13), type 1 T 
      helper (IFN-gamma), and pro-inflammatory cytokines (TNF-alpha and IL-6), but not 
      anti-inflammatory cytokine (IL-10) from splenocytes of OVA-sensitized mice 
      against OVA re-stimulation. A population of T regulatory (Treg) cells with 
      immunosuppressive properties was increased in mesenteric lymph nodes and spleen 
      of PGG-fed mice. PGG administration not only reduced expression levels of 
      eotaxin, tissue inhibitors of metalloproteinases-1, and TNF-alpha, which assisted 
      with IgE production, but also increased the expression of insulin-like growth 
      factor binding protein-3 which inhibits IgE production. Additionally, PGG 
      increased the levels of Treg cell-inducing factors such as IL-2, IL-10 and 
      platelet factor-4 in serum. These data suggest that the inhibitory effect of PGG 
      on IgE production could be partially caused by increasing a population of Treg 
      cells in conjunction with Treg-inducing factors.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Kim, Yoon Hee
AU  - Kim YH
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Yang, Xue
AU  - Yang X
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Yamashita, Shuya
AU  - Yamashita S
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Kumazoe, Motofumi
AU  - Kumazoe M
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Huang, Yuhui
AU  - Huang Y
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Nakahara, Kanami
AU  - Nakahara K
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Won, Yeong Seon
AU  - Won YS
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Murata, Motoki
AU  - Murata M
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Lin, I-Chian
AU  - Lin IC
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan.
FAU - Tachibana, Hirofumi
AU  - Tachibana H
AD  - Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu 
      University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan; Food Functional 
      Design Research Center, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 
      812-8581, Japan. Electronic address: tatibana@agr.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150228
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Anti-Allergic Agents)
RN  - 0 (Cytokines)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Foxp3 protein, mouse)
RN  - 0 (Hydrolyzable Tannins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3UI3K8W93I (pentagalloylglucose)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Allergic Agents/administration & dosage/adverse effects/*therapeutic use
MH  - Cytokines/blood
MH  - Disease Models, Animal
MH  - Forkhead Transcription Factors/biosynthesis
MH  - Hydrolyzable Tannins/administration & dosage/adverse effects/*therapeutic use
MH  - Hypersensitivity, Immediate/blood/*drug therapy/immunology
MH  - Immunoglobulin E/*biosynthesis/immunology
MH  - Lymphocyte Count
MH  - Male
MH  - Mice, Inbred BALB C
MH  - Ovalbumin/immunology
MH  - Spleen/drug effects/immunology
MH  - T-Lymphocytes, Regulatory/*cytology/immunology
OTO - NOTNLM
OT  - Gallotannin
OT  - IgE
OT  - PGG
OT  - T regulatory cell
EDAT- 2015/03/05 06:00
MHDA- 2016/02/18 06:00
CRDT- 2015/03/05 06:00
PHST- 2014/12/23 00:00 [received]
PHST- 2015/01/27 00:00 [revised]
PHST- 2015/02/16 00:00 [accepted]
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2016/02/18 06:00 [medline]
AID - S1567-5769(15)00072-7 [pii]
AID - 10.1016/j.intimp.2015.02.025 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2015 May;26(1):30-6. doi: 10.1016/j.intimp.2015.02.025. Epub 
      2015 Feb 28.