PMID- 25737233
OWN - NLM
STAT- MEDLINE
DCOM- 20160526
LR  - 20160115
IS  - 1479-8301 (Electronic)
IS  - 1346-3500 (Linking)
VI  - 15
IP  - 4
DP  - 2015 Dec
TI  - Relationship between dementia severity and behavioural and psychological symptoms 
      in early-onset Alzheimer's disease.
PG  - 242-7
LID - 10.1111/psyg.12108 [doi]
AB  - BACKGROUND: The features of behavioural and psychological symptoms of dementia 
      (BPSD) are influenced by dementia stage. In early-onset Alzheimer's disease 
      (EOAD), the association between BPSD and dementia stage remains unclear because 
      of the difficulty of recruiting subjects with a wide range of disease severity. 
      We used a combination of community-based and hospital-based approaches to 
      investigate the relationship between dementia severity and BPSD in EOAD patients. 
      METHODS: Sixty-three consecutive EOAD outpatients and 29 EOAD patients from a 
      community-based survey were divided into three dementia severity groups according 
      to the Clinical Dementia Rating scale (CDR): mild (CDR 0.5-1, n = 55), moderate 
      (CDR 2, n = 17), and severe (CDR 3, n = 20). BPSD were rated using the 
      Neuropsychiatric Inventory. RESULTS: Scores of the Neuropsychiatric Inventory 
      subscales agitation, euphoria, apathy, disinhibition, irritability, and aberrant 
      motor behaviour increased significantly with increased dementia severity. 
      Hallucinations were greater in the moderate group than in the mild group. For 
      delusions, depression, and anxiety, no significant differences were observed 
      among the three severity groups. CONCLUSIONS: The pattern of apathy, agitation, 
      disinhibition, irritability, and aberrant motor behaviour worsening with severity 
      progression in EOAD is similar to the pattern in late-onset Alzheimer's disease. 
      In contrast, hallucinations, depression, and anxiety showed different patterns in 
      EOAD.
CI  - (c) 2015 The Authors. Psychogeriatrics (c) 2015 Japanese Psychogeriatric Society.
FAU - Tanaka, Hibiki
AU  - Tanaka H
AD  - Department of Neuropsychiatry, Graduate School of Medical Science, Kumamoto 
      University, Kumamoto, Japan.
FAU - Hashimoto, Mamoru
AU  - Hashimoto M
AD  - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 
      Kumamoto, Japan.
FAU - Fukuhara, Ryuji
AU  - Fukuhara R
AD  - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 
      Kumamoto, Japan.
FAU - Ishikawa, Tomohisa
AU  - Ishikawa T
AD  - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 
      Kumamoto, Japan.
FAU - Yatabe, Yusuke
AU  - Yatabe Y
AD  - Mental Health and Welfare Center in Kumamoto Prefecture, Kumamoto, Japan.
FAU - Kaneda, Keiichiro
AU  - Kaneda K
AD  - Department of Psychiatry, Kumamoto Seimei Hospital, Kumamoto, Japan.
FAU - Yuuki, Seiji
AU  - Yuuki S
AD  - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 
      Kumamoto, Japan.
FAU - Honda, Kazuki
AU  - Honda K
AD  - Department of Psychiatry, Kikuchi National Hospital, Kumamoto, Japan.
FAU - Matsuzaki, Shiho
AU  - Matsuzaki S
AD  - Department of Neuropsychiatry, Graduate School of Medical Science, Kumamoto 
      University, Kumamoto, Japan.
FAU - Tsuyuguchi, Atsuko
AU  - Tsuyuguchi A
AD  - Department of Neuropsychiatry, Graduate School of Medical Science, Kumamoto 
      University, Kumamoto, Japan.
FAU - Hatada, Yutaka
AU  - Hatada Y
AD  - Department of Neuropsychiatry, Graduate School of Medical Science, Kumamoto 
      University, Kumamoto, Japan.
FAU - Ikeda, Manabu
AU  - Ikeda M
AD  - Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, 
      Kumamoto, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150303
PL  - England
TA  - Psychogeriatrics
JT  - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society
JID - 101230058
SB  - IM
MH  - Affective Symptoms/psychology
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*psychology
MH  - Anxiety/complications/diagnosis/psychology
MH  - Behavioral Symptoms/*psychology
MH  - Delusions/complications/diagnosis/psychology
MH  - Dementia/*psychology
MH  - Depression/complications/diagnosis/psychology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Psychiatric Status Rating Scales
MH  - Psychomotor Agitation/psychology
MH  - Psychotic Disorders/psychology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Neuropsychiatric Inventory (NPI)
OT  - behavioural and psychological symptoms (BPSD)
OT  - early-onset
OT  - severity of dementia
EDAT- 2015/03/05 06:00
MHDA- 2016/05/27 06:00
CRDT- 2015/03/05 06:00
PHST- 2014/11/19 00:00 [received]
PHST- 2014/12/22 00:00 [revised]
PHST- 2014/12/24 00:00 [accepted]
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2016/05/27 06:00 [medline]
AID - 10.1111/psyg.12108 [doi]
PST - ppublish
SO  - Psychogeriatrics. 2015 Dec;15(4):242-7. doi: 10.1111/psyg.12108. Epub 2015 Mar 3.