PMID- 25737972
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150304
LR  - 20240322
IS  - 2249-782X (Print)
IS  - 0973-709X (Electronic)
IS  - 0973-709X (Linking)
VI  - 9
IP  - 1
DP  - 2015 Jan
TI  - The evaluation of serum levels of testosterone in type 2 diabetic men and its 
      relation with lipid profile.
PG  - BC04-7
LID - 10.7860/JCDR/2015/11049.5381 [doi]
AB  - INTRODUCTION AND AIM: Type 2 diabetes mellitus (T2DM) is the predominant form of 
      diabetes worldwide and much is known about its patho-physiology. Yet, newer 
      aspects related to it are being constantly explored. For ages, testosterone has 
      been known to men as the male sex hormone but now it has been shown by certain 
      studies that it might have a role in the development of metabolic disorders like 
      type 2 diabetes. This study was carried out to determine the relation of 
      testosterone levels with type 2 diabetes mellitus and lipid profile in North East 
      Indian men aged 31 to 73 years. MATERIALS AND METHODS: This case control study 
      comprised of 40 type 2 diabetic men and 40 age matched non diabetic healthy men. 
      Testosterone, SHBG levels and lipid profile were evaluated in both the groups 
      along with anthropometric measurements and were statistically analysed. RESULTS: 
      Serum total and free testosterone and Sex Hormone Binding Globulin were 
      significantly lower in the test group than in the control group. Prevalence of 
      type 2diabetes was five times higher in men having a total testosterone less than 
      8nmol/L and 5.57 times higher in those having a free testosterone of less than 
      0.225nmol/L. Fasting blood glucose showed a strong negative correlation with 
      total and free testosterone. Glycated haemoglobin correlated negatively with SHBG 
      but no such correlation was seen with total or free testosterone. Serum total and 
      LDL cholesterol showed significant negative correlation with total testosterone 
      and SHBG but no significant correlation was found with free testosterone. Serum 
      VLDL, HDL and triglycerides did not show any significant correlation with total 
      or free testosterone and SHBG levels. CONCLUSION: Low testosterone might have a 
      role in the development of type 2 DM and to the associated altered lipid profile. 
      This study, though a small one is among the few of its kind in India and it 
      thrives to assist other studies related to the matter.
FAU - Mattack, Nirmali
AU  - Mattack N
AD  - Post-Graduate Trainee, Department of Biochemistry, Gauhati Medical College & 
      Hospital , Guwahati, Assam, India .
FAU - Devi, Runi
AU  - Devi R
AD  - Professor, Department of Biochemistry, Gauhati Medical College & Hospital , 
      Guwahati, Assam, India .
FAU - Kutum, Tridip
AU  - Kutum T
AD  - Post-Graduate Trainee, Department of Biochemistry, Gauhati Medical College & 
      Hospital , Guwahati, Assam, India .
FAU - Patgiri, Dibyaratna
AU  - Patgiri D
AD  - Demonstrator, Department of Biochemistry, Gauhati Medical College & Hospital , 
      Guwahati, Assam, India .
LA  - eng
PT  - Journal Article
DEP - 20150101
PL  - India
TA  - J Clin Diagn Res
JT  - Journal of clinical and diagnostic research : JCDR
JID - 101488993
PMC - PMC4347063
OTO - NOTNLM
OT  - Dyslipidemia
OT  - Serum free testosterone
OT  - Serum total testosterone
OT  - Sex hormone binding globulin
OT  - Type 2 diabetes
EDAT- 2015/03/05 06:00
MHDA- 2015/03/05 06:01
PMCR- 2015/03/01
CRDT- 2015/03/05 06:00
PHST- 2014/09/01 00:00 [received]
PHST- 2014/10/30 00:00 [accepted]
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2015/03/05 06:01 [medline]
PHST- 2015/03/01 00:00 [pmc-release]
AID - 10.7860/JCDR/2015/11049.5381 [doi]
PST - ppublish
SO  - J Clin Diagn Res. 2015 Jan;9(1):BC04-7. doi: 10.7860/JCDR/2015/11049.5381. Epub 
      2015 Jan 1.