PMID- 25738851
OWN - NLM
STAT- MEDLINE
DCOM- 20151214
LR  - 20220321
IS  - 1545-9616 (Print)
IS  - 1545-9616 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Mar
TI  - 12-month effects of stabilized hyaluronic acid gel compared with saline for 
      rejuvenation of aging hands.
PG  - 288-98
AB  - In this evaluator-blind, placebo-controlled study, microinjections of stabilized 
      hyaluronic acid (HA) gel for rejuvenation of aging hands were evaluated. Patients 
      received three injections of 1.0 ml HA gel (20 mg/ml HA) in the dorsum of one 
      hand and 1.0 ml saline in the other, over 3 months (M). Treatments were compared 
      up to M03; comparisons with Day 1 (D01) were made up to M05 and M12 (extension 
      study). Efficacy was evaluated by patients and investigators using the Global 
      Aesthetic Improvement Scale (GAIS). Self-assessment questionnaires, biomechanical 
      measurements, and adverse events (AEs) were analyzed. Thirty women (mean age: 53 
      years) provided data up to M05. At M03, HA gel treatment improved hand skin 
      condition in all patients versus D01, according to the GAIS; improvements were 
      sustained to M12. Mean patient scores at M01-M03 were significantly higher for HA 
      gel than for saline (P<0.05). Self-assessment questionnaire grades up to M03 were 
      generally significantly better for HA gel versus saline (P<0.05); grades were 
      maintained to M12. Statistically significant improvements with HA gel in 
      hydration and elasticity was demonstrated at M03, compared with D01 and saline 
      (P<0.05), and in terms of skin roughness versus D01. Maximum roughness (P<0.05) 
      and waviness (P<0.01) were significantly improved versus saline. All AEs were 
      mild and anticipated, with no serious AEs. Overall, HA gel injections were 
      generally well tolerated and efficacious for rejuvenation of aging hands compared 
      with saline. Sustained improvements at 12 months compared with baseline indicate 
      that efficacy could be maintained long term.
FAU - Gubanova, Elena I
AU  - Gubanova EI
FAU - Starovatova, Polina A
AU  - Starovatova PA
FAU - Rodina, Maria Y
AU  - Rodina MY
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Drugs Dermatol
JT  - Journal of drugs in dermatology : JDD
JID - 101160020
RN  - 0 (Viscosupplements)
RN  - 451W47IQ8X (Sodium Chloride)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cosmetic Techniques/instrumentation
MH  - Female
MH  - *Hand/pathology
MH  - Humans
MH  - Hyaluronic Acid/*administration & dosage
MH  - Microinjections
MH  - Middle Aged
MH  - *Patient Satisfaction
MH  - Prospective Studies
MH  - *Rejuvenation/physiology
MH  - Single-Blind Method
MH  - Skin Aging/*drug effects/physiology
MH  - Sodium Chloride/*administration & dosage
MH  - Time Factors
MH  - Treatment Outcome
MH  - Viscosupplements/administration & dosage
EDAT- 2015/03/05 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/03/05 06:00
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - S1545961615P0288X [pii]
PST - ppublish
SO  - J Drugs Dermatol. 2015 Mar;14(3):288-98.