PMID- 25739024
OWN - NLM
STAT- MEDLINE
DCOM- 20151120
LR  - 20220331
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 3
DP  - 2015
TI  - Alterations of BDNF and trkB mRNA expression in the 6-hydroxydopamine-induced 
      model of preclinical stages of Parkinson's disease: an influence of chronic 
      pramipexole in rats.
PG  - e0117698
LID - 10.1371/journal.pone.0117698 [doi]
LID - e0117698
AB  - Our recent study has indicated that a moderate lesion of the mesostriatal and 
      mesolimbic pathways in rats, modelling preclinical stages of Parkinson's disease, 
      induces a depressive-like behaviour which is reversed by chronic treatment with 
      pramipexole. The purpose of the present study was to examine the role of brain 
      derived neurotrophic factor (BDNF) signalling in the aforementioned model of 
      depression. Therefore, we investigated the influence of 6-hydoxydopamine (6-OHDA) 
      administration into the ventral region of the caudate-putamen on mRNA levels of 
      BDNF and tropomyosin-related kinase B (trkB) receptor. The BDNF and trkB mRNA 
      levels were determined in the nigrostriatal and limbic structures by in situ 
      hybridization 2 weeks after the operation. Pramipexole (1 mg/kg sc twice a day) 
      and imipramine (10 mg/kg ip once a day) were injected for 2 weeks. The lesion 
      lowered the BDNF and trkB mRNA levels in the hippocampus [CA1, CA3 and dentate 
      gyrus (DG)] and amygdala (basolateral/lateral) as well as the BDNF mRNA content 
      in the habenula (medial/lateral). The lesion did not influence BDNF and trkB 
      expression in the caudate-putamen, substantia nigra, nucleus accumbens (shell and 
      core) and ventral tegmental area (VTA). Chronic imipramine reversed the 
      lesion-induced decreases in BDNF mRNA in the DG. Chronic pramipexole increased 
      BDNF mRNA, but decreased trkB mRNA in the VTA in lesioned rats. Furthermore, it 
      reduced BDNF and trkB mRNA expression in the shell and core of the nucleus 
      accumbens, BDNF mRNA in the amygdala and trkB mRNA in the caudate-putamen in 
      these animals. The present study indicates that both the 6-OHDA-induced 
      dopaminergic lesion and chronic pramipexole influence BDNF signalling in limbic 
      structures, which may be related to their pro-depressive and antidepressant 
      activity in rats, respectively.
FAU - Berghauzen-Maciejewska, Klemencja
AU  - Berghauzen-Maciejewska K
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
FAU - Wardas, Jadwiga
AU  - Wardas J
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
FAU - Kosmowska, Barbara
AU  - Kosmowska B
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
FAU - Glowacka, Urszula
AU  - Glowacka U
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
FAU - Kuter, Katarzyna
AU  - Kuter K
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
FAU - Ossowska, Krystyna
AU  - Ossowska K
AD  - Department of Neuro-Psychopharmacology, Institute of Pharmacology, Polish Academy 
      of Sciences, 12 Smetna St., 31-343, Krakow, Poland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150304
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antiparkinson Agents)
RN  - 0 (Benzothiazoles)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 83619PEU5T (Pramipexole)
RN  - 8HW4YBZ748 (Oxidopamine)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Antiparkinson Agents/*pharmacology/therapeutic use
MH  - Benzothiazoles/*pharmacology/therapeutic use
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Male
MH  - Oxidopamine/toxicity
MH  - Parkinson Disease/drug therapy/etiology/*metabolism
MH  - Pramipexole
MH  - RNA, Messenger/genetics/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/genetics/*metabolism
PMC - PMC4349741
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/03/05 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/03/04
CRDT- 2015/03/05 06:00
PHST- 2014/10/03 00:00 [received]
PHST- 2014/12/30 00:00 [accepted]
PHST- 2015/03/05 06:00 [entrez]
PHST- 2015/03/05 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/03/04 00:00 [pmc-release]
AID - PONE-D-14-44504 [pii]
AID - 10.1371/journal.pone.0117698 [doi]
PST - epublish
SO  - PLoS One. 2015 Mar 4;10(3):e0117698. doi: 10.1371/journal.pone.0117698. 
      eCollection 2015.