PMID- 25739570
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20161125
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 79
IP  - 4
DP  - 2015
TI  - Notched QRS for the assessment of myocardial fibrosis in hypertrophic 
      cardiomyopathy.
PG  - 847-53
LID - 10.1253/circj.CJ-14-1109 [doi]
AB  - BACKGROUND: Patients with hypertrophic cardiomyopathy (HCM) sometimes develop 
      myocardial fibrosis in association with adverse cardiovascular events. 
      Electrocardiography (ECG) could provide helpful information on myocardial 
      fibrosis in HCM, as in coronary artery disease. METHODS AND RESULTS: A total of 
      60 patients with HCM without bundle branch block underwent cardiac magnetic 
      resonance imaging (CMR). The extent or location of late gadolinium enhancement 
      (LGE) was examined in relation to 12-lead ECG. A notch on QRS was defined as at 
      least 2 consecutive spikes in the same polarity with a reversal of direction >/=90 degrees  
      and the initial negative deflection >/=0.05 mV. LGE was associated with notched 
      QRS, leftward QRS axis, and prolonged QRS duration, but not with any other 
      findings such as abnormal Q waves, R-wave amplitude, or ST-T changes. Notched QRS 
      was most useful in determining the presence or absence of myocardial fibrosis, 
      with a sensitivity of 70% and a specificity of 81% using a cut-off of the number 
      of leads with notched QRS >/=2. The number of notched QRS leads was positively 
      correlated with LGE volume (P<0.01) and the lead distribution of notched QRS was 
      informative about the location of LGE. CONCLUSIONS: A notch on QRS was useful in 
      estimating myocardial fibrosis as assessed on CMR LGE in HCM patients without 
      bundle branch block.
FAU - Kawasaki, Tatsuya
AU  - Kawasaki T
AD  - Department of Cardiology, Matsushita Memorial Hospital.
FAU - Harimoto, Kuniyasu
AU  - Harimoto K
FAU - Honda, Sakiko
AU  - Honda S
FAU - Sato, Yoshimi
AU  - Sato Y
FAU - Yamano, Michiyo
AU  - Yamano M
FAU - Miki, Shigeyuki
AU  - Miki S
FAU - Kamitani, Tadaaki
AU  - Kamitani T
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150128
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Contrast Media)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiomegaly/*diagnostic imaging/*physiopathology
MH  - Contrast Media/administration & dosage
MH  - *Electrocardiography
MH  - Female
MH  - Fibrosis/diagnostic imaging/physiopathology
MH  - Gadolinium/administration & dosage
MH  - Humans
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Radiography
EDAT- 2015/03/06 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/03/06 06:00
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 10.1253/circj.CJ-14-1109 [doi]
PST - ppublish
SO  - Circ J. 2015;79(4):847-53. doi: 10.1253/circj.CJ-14-1109. Epub 2015 Jan 28.