PMID- 25740197
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220408
IS  - 1552-485X (Electronic)
IS  - 1552-4841 (Linking)
VI  - 168B
IP  - 3
DP  - 2015 Apr
TI  - RGS2 ggenetic variation: association analysis with panic disorder and dimensional 
      as well as intermediate phenotypes of anxiety.
PG  - 211-22
LID - 10.1002/ajmg.b.32299 [doi]
AB  - Accumulating evidence from mouse models points to the G protein-coupled receptor 
      RGS2 (regulator of G-protein signaling 2) as a promising candidate gene for 
      anxiety in humans. Recently, RGS2 polymorphisms were found to be associated with 
      various anxiety disorders, e.g., rs4606 with panic disorder (PD), but other 
      findings have been negative or inconsistent concerning the respective risk 
      allele. To further examine the role of RGS2 polymorphisms in the pathogenesis of 
      PD, we genotyped rs4606 and five additional RGS2 tag single nucleotide 
      polymorphisms (SNPs; rs16834831, rs10801153, rs16829458, rs1342809, rs1890397) in 
      two independent PD samples, comprising 531 matched case/control pairs. The 
      functional SNP rs4606 was nominally associated with PD when both samples were 
      combined. The upstream SNP rs10801153 displayed a Bonferroni-resistant 
      significant association with PD in the second and the combined sample (P = 0.006 
      and P = 0.017). We furthermore investigated the effect of rs10801153 on 
      dimensional anxiety traits, a behavioral avoidance test (BAT), and an index for 
      emotional processing in the respective subsets of the total sample. In line with 
      categorical results, homozygous risk (G) allele carriers displayed higher scores 
      on the Agoraphobic Cognitions Questionnaire (ACQ; P = 0.015) and showed 
      significantly more defensive behavior during fear provoking situations 
      (P = 0.001). Furthermore, significant effects on brain activation in response to 
      angry (P = 0.013), happy (P = 0.042) and neutral faces (P = 0.032) were detected. 
      Taken together, these findings provide further evidence for the potential role of 
      RGS2 as a candidate gene for PD.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Hohoff, Christa
AU  - Hohoff C
AD  - Department of Psychiatry and Psychotherapy, University of Muenster, Muenster, 
      Germany.
FAU - Weber, Heike
AU  - Weber H
FAU - Richter, Jan
AU  - Richter J
FAU - Domschke, Katharina
AU  - Domschke K
FAU - Zwanzger, Peter M
AU  - Zwanzger PM
FAU - Ohrmann, Patricia
AU  - Ohrmann P
FAU - Bauer, Jochen
AU  - Bauer J
FAU - Suslow, Thomas
AU  - Suslow T
FAU - Kugel, Harald
AU  - Kugel H
FAU - Baumann, Christian
AU  - Baumann C
FAU - Klauke, Benedikt
AU  - Klauke B
FAU - Jacob, Christian P
AU  - Jacob CP
FAU - Fritze, Jurgen
AU  - Fritze J
FAU - Bandelow, Borwin
AU  - Bandelow B
FAU - Gloster, Andrew T
AU  - Gloster AT
FAU - Gerlach, Alexander L
AU  - Gerlach AL
FAU - Kircher, Tilo
AU  - Kircher T
FAU - Lang, Thomas
AU  - Lang T
FAU - Alpers, Georg W
AU  - Alpers GW
FAU - Strohle, Andreas
AU  - Strohle A
FAU - Fehm, Lydia
AU  - Fehm L
FAU - Wittchen, Hans-Ulrich
AU  - Wittchen HU
FAU - Arolt, Volker
AU  - Arolt V
FAU - Pauli, Paul
AU  - Pauli P
FAU - Hamm, Alfons
AU  - Hamm A
FAU - Reif, Andreas
AU  - Reif A
FAU - Deckert, Jurgen
AU  - Deckert J
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150304
PL  - United States
TA  - Am J Med Genet B Neuropsychiatr Genet
JT  - American journal of medical genetics. Part B, Neuropsychiatric genetics : the 
      official publication of the International Society of Psychiatric Genetics
JID - 101235742
RN  - 0 (Biomarkers)
RN  - 0 (RGS Proteins)
RN  - 0 (RGS2 protein, human)
SB  - IM
MH  - Adult
MH  - Anxiety Disorders/*etiology/psychology
MH  - Biomarkers/*analysis
MH  - Brain Mapping
MH  - Case-Control Studies
MH  - Emotions/physiology
MH  - Female
MH  - Follow-Up Studies
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Male
MH  - Panic Disorder/complications/*genetics/psychology
MH  - Personality
MH  - Phenotype
MH  - Pilot Projects
MH  - Polymorphism, Single Nucleotide/*genetics
MH  - Prognosis
MH  - Psychological Tests
MH  - RGS Proteins/*genetics
OTO - NOTNLM
OT  - anxiety
OT  - fear
OT  - panic disorder
OT  - polymorphism
OT  - regulator of G-protein signaling 2
EDAT- 2015/03/06 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/03/06 06:00
PHST- 2014/05/30 00:00 [received]
PHST- 2015/01/14 00:00 [accepted]
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 10.1002/ajmg.b.32299 [doi]
PST - ppublish
SO  - Am J Med Genet B Neuropsychiatr Genet. 2015 Apr;168B(3):211-22. doi: 
      10.1002/ajmg.b.32299. Epub 2015 Mar 4.