PMID- 25740233 OWN - NLM STAT- MEDLINE DCOM- 20160830 LR - 20181202 IS - 1880-2206 (Electronic) IS - 1347-3182 (Linking) VI - 14 IP - 2 DP - 2015 TI - MRI-based evidence for myocardial involvement in women with hypereosinophilic syndrome. PG - 107-14 AB - PURPOSE: The aim of the study was to assess the presence and spectrum of cardiac abnormalities identified by cardiac magnetic resonance (CMR) in women with hypereosinophilic syndrome (HES) of undefined etiology, who present with normal electrocardiography (ECG) and transthoracic echocardiography (TTE) and no history of heart disease. METHODS: Ten women (mean age, 48 +/- 14 years) with HES of undefined etiology, normal ECG and TTE, and no history of heart disease underwent CMR. RESULTS: CMR showed cardiac abnormalities in 6 subjects. Five patients had nonischemic late gadolinium enhancement (LGE) lesions within the left ventricular (LV) myocardium, and 3 patients demonstrated CMR evidence of myocardial inflammation. The LV ejection fraction was 68.5 +/- 5.7%, and the end-diastolic volume index was 62.7 +/- 14.7 mL/m(2). The maximum measured blood eosinophil count correlated with LVLGE volume (r = 0.80, P = 0.006) and was 11374 +/- 6242 cells/muL and 4114 +/- 2972 cells/muL (P = 0.047) in patients with and without LGE lesions, respectively. The actual blood eosinophil count in subjects with and without CMR evidence of myocarditis was 1058 +/- 520 cells/muL and 354 +/- 377 cells/muL (P = 0.04), respectively. CONCLUSIONS: Despite normal ECG, TTE, and absence of history of heart disease, women with HES of unknown etiology frequently demonstrate cardiac abnormalities on CMR, the presence and extent of which are related to blood eosinophil count. FAU - Miszalski-Jamka, Tomasz AU - Miszalski-Jamka T AD - Department of Medicine, Jagiellonian University Medical College ul. Skawinska 8, 31-066 Krakow, Poland; Department of Radiology and Imaging Diagnostics, John Paul II Hospital, Krakow, Poland; Center for Heart Disease, Clinical Military Hospital, Wroclaw, Poland. miszalt@mp.pl FAU - Szczeklik, Wojciech AU - Szczeklik W FAU - Karwat, Krzysztof AU - Karwat K FAU - Sokolowska, Barbara AU - Sokolowska B FAU - Gasior, Jolanta AU - Gasior J FAU - Rucinska, Malgorzata AU - Rucinska M FAU - Mazur, Wojciech AU - Mazur W FAU - Skotnicki, Aleksander AU - Skotnicki A FAU - Kereiakes, Dean J AU - Kereiakes DJ FAU - Urbanczyk, Malgorzata AU - Urbanczyk M FAU - Jazwiec, Przemyslaw AU - Jazwiec P FAU - Musial, Jacek AU - Musial J LA - eng PT - Journal Article PL - Japan TA - Magn Reson Med Sci JT - Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine JID - 101153368 RN - 0 (Contrast Media) RN - AU0V1LM3JT (Gadolinium) RN - K2I13DR72L (Gadolinium DTPA) SB - IM MH - Adult MH - Aged MH - Cardiomyopathies/*diagnosis/diagnostic imaging MH - Contrast Media MH - Echocardiography/methods MH - Electrocardiography/methods MH - Eosinophils/pathology MH - Female MH - Follow-Up Studies MH - Gadolinium MH - Gadolinium DTPA MH - Heart Ventricles/pathology MH - Humans MH - Hypereosinophilic Syndrome/blood/*complications MH - Image Processing, Computer-Assisted/methods MH - Leukocyte Count MH - Magnetic Resonance Imaging/*methods MH - Magnetic Resonance Imaging, Cine/methods MH - Male MH - Middle Aged MH - Myocarditis/diagnosis MH - Stroke Volume/physiology MH - Ventricular Function, Left/physiology MH - Ventricular Function, Right/physiology MH - Young Adult EDAT- 2015/03/06 06:00 MHDA- 2016/08/31 06:00 CRDT- 2015/03/06 06:00 PHST- 2015/03/06 06:00 [entrez] PHST- 2015/03/06 06:00 [pubmed] PHST- 2016/08/31 06:00 [medline] AID - 10.2463/mrms.2013-0133 [doi] PST - ppublish SO - Magn Reson Med Sci. 2015;14(2):107-14. doi: 10.2463/mrms.2013-0133.