PMID- 25740606
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20150513
IS  - 1438-2199 (Electronic)
IS  - 0939-4451 (Linking)
VI  - 47
IP  - 6
DP  - 2015 Jun
TI  - Maternal L-glutamine supplementation prevents prenatal alcohol exposure-induced 
      fetal growth restriction in an ovine model.
PG  - 1183-92
LID - 10.1007/s00726-015-1945-x [doi]
AB  - Prenatal alcohol exposure is known to cause fetal growth restriction and 
      disturbances in amino acid bioavailability. Alterations in these parameters can 
      persist into adulthood and low birth weight can lead to altered fetal 
      programming. Glutamine has been associated with the synthesis of other amino 
      acids, an increase in protein synthesis and it is used clinically as a nutrient 
      supplement for low birth weight infants. The aim of this study was to explore the 
      effect of repeated maternal alcohol exposure and L-glutamine supplementation on 
      fetal growth and amino acid bioavailability during the third trimester-equivalent 
      period in an ovine model. Pregnant sheep were randomly assigned to four groups, 
      saline control, alcohol (1.75-2.5 g/kg), glutamine (100 mg/kg, three times daily) 
      or alcohol + glutamine. In this study, a weekend binge drinking model was 
      followed where treatment was done 3 days per week in succession from gestational 
      day (GD) 109-132 (normal term ~147). Maternal alcohol exposure significantly 
      reduced fetal body weight, height, length, thoracic girth and brain weight, and 
      resulted in decreased amino acid bioavailability in fetal plasma and placental 
      fluids. Maternal glutamine supplementation successfully mitigated alcohol-induced 
      fetal growth restriction and improved the bioavailability of glutamine and 
      glutamine-related amino acids such as glycine, arginine, and asparagine in the 
      fetal compartment. All together, these findings show that L-glutamine 
      supplementation enhances amino acid availability in the fetus and prevents 
      alcohol-induced fetal growth restriction.
FAU - Sawant, Onkar B
AU  - Sawant OB
AD  - Department of Veterinary Physiology and Pharmacology, Michael E. DeBakey 
      Institute, College of Veterinary Medicine and Biomedical Sciences, Texas A&M 
      University, College Station, TX, 77843-4466, USA.
FAU - Wu, Guoyao
AU  - Wu G
FAU - Washburn, Shannon E
AU  - Washburn SE
LA  - eng
GR  - AA010940/AA/NIAAA NIH HHS/United States
GR  - AA18166-2/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150305
PL  - Austria
TA  - Amino Acids
JT  - Amino acids
JID - 9200312
RN  - 0RH81L854J (Glutamine)
SB  - IM
MH  - Animals
MH  - *Dietary Supplements
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/metabolism/pathology/*prevention & control
MH  - Fetal Growth Retardation/chemically induced/metabolism/pathology/*prevention & 
      control
MH  - Glutamine/*pharmacology
MH  - Pregnancy
MH  - Sheep
EDAT- 2015/03/06 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/03/06 06:00
PHST- 2015/01/21 00:00 [received]
PHST- 2015/02/16 00:00 [accepted]
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - 10.1007/s00726-015-1945-x [doi]
PST - ppublish
SO  - Amino Acids. 2015 Jun;47(6):1183-92. doi: 10.1007/s00726-015-1945-x. Epub 2015 
      Mar 5.