PMID- 25740668
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20150326
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 79
IP  - 4
DP  - 2015
TI  - Thin cap fibroatheroma defined as lipid core abutting lumen (LCAL) on integrated 
      backscatter intravascular ultrasound - comparison with optical coherence 
      tomography and correlation with peri-procedural myocardial infarction.
PG  - 808-17
LID - 10.1253/circj.CJ-14-0758 [doi]
AB  - BACKGROUND: This study evaluated the ability of a newly developed integrated 
      backscatter intravascular ultrasound (IB-IVUS) system (VISIWAVE, Terumo, Tokyo, 
      Japan) to detect optical coherence tomography (OCT)-verified thin cap 
      fibroatheroma (TCFA) and assessed the correlation with peri-procedural myocardial 
      infarction (PMI) after percutaneous coronary intervention (PCI). METHODS AND 
      RESULTS: One hundred culprit lesions in 100 consecutive patients with ischemic 
      heart disease who consented to repeated IVUS and OCT prior to PCI were studied. 
      Of 100 lesions, 48 had OCT-verified TCFA with a cap thickness <65 microm. Such 
      lesions had larger percentage lipid area and lipid angle >2 quadrants on IB-IVUS. 
      A lipid core abutting lumen (LCAL) was defined as a lipid core pool in the plaque 
      area, directly contacting with the lumen regardless of its circumferential 
      extension. IB-IVUS-identified TCFA defined as a combination of percentage lipid 
      area >/=53.6%, remodeling index >/=1.03, and the presence of LCAL was the best 
      predictor of OCT-verified TCFA with sensitivity, specificity, positive and 
      negative predictive values, and accuracy of 72.9%, 90.4%, 87.5%, 78.3%, and 
      82.0%, respectively. IB-IVUS-identified TCFA as well as OCT-verified TCFA were 
      significant independent predictors of PMI, after adjusting for other predictors 
      on multivariate analysis. CONCLUSIONS: IB-IVUS can be used to identify plaques 
      with a high prevalence of TCFA. Such techniques can therefore potentially be used 
      to identify lesions with an elevated risk of PMI after PCI.
FAU - Ozaki, Yukio
AU  - Ozaki Y
AD  - Department of Cardiology, Fujita Health University Hospital.
FAU - Ohota, Masaya
AU  - Ohota M
FAU - Ismail, Tevfik F
AU  - Ismail TF
FAU - Okumura, Masanori
AU  - Okumura M
FAU - Ishikawa, Masato
AU  - Ishikawa M
FAU - Muramatsu, Takashi
AU  - Muramatsu T
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150213
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Lipids)
SB  - IM
CIN - Circ J. 2015;79(4):754-5. PMID: 25753855
MH  - Aged
MH  - Female
MH  - Humans
MH  - *Lipids
MH  - Male
MH  - Middle Aged
MH  - *Myocardial Infarction/etiology/pathology
MH  - Percutaneous Coronary Intervention/*adverse effects
MH  - Plaque, Atherosclerotic/pathology/surgery
MH  - Postoperative Complications/*pathology
MH  - *Tomography, Optical Coherence
MH  - *Ultrasonography, Interventional
EDAT- 2015/03/06 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/03/06 06:00
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - 10.1253/circj.CJ-14-0758 [doi]
PST - ppublish
SO  - Circ J. 2015;79(4):808-17. doi: 10.1253/circj.CJ-14-0758. Epub 2015 Feb 13.