PMID- 25741153
OWN - NLM
STAT- MEDLINE
DCOM- 20150928
LR  - 20181113
IS  - 2219-2840 (Electronic)
IS  - 1007-9327 (Print)
IS  - 1007-9327 (Linking)
VI  - 21
IP  - 8
DP  - 2015 Feb 28
TI  - Nasobiliary drainage after endoscopic papillary balloon dilatation may prevent 
      postoperative pancreatitis.
PG  - 2443-9
LID - 10.3748/wjg.v21.i8.2443 [doi]
AB  - AIM: To evaluate the necessity of endoscopic nasobiliary drainage (ENBD) catheter 
      placement after clearance of common bile duct (CBD) stones. METHODS: Patients 
      enrolled in this study were randomly divided into two groups, according to 
      whether or not they received ENBD after the removal of CBD stones. Group 1 (ENBD 
      group) was then subdivided into three groups: G1a patients received an endoscopic 
      papillary balloon dilatation (EPBD), G1b patients received an endoscopic 
      sphincterotomy (EST), and G1c patients received neither. Group 2 (non-ENBD group) 
      patients were also subdivided into three groups (G2a, G2b, and G2c), similar to 
      Group 1. The maximum CBD diameter, the time for C-reactive protein (CRP) to 
      normalize, levels of serum amylase, total serum bilirubin (TB) and alanine 
      aminotransferase (ALT), and postoperative hospitalization duration (PHD) were 
      measured. RESULTS: A total of 218 patients (139 males, 79 females), with an 
      average age of 60.1+/-10.8 years, were enrolled in this study. One hundred and 
      thirteen patients who received ENBD were included in Group 1, and 105 patients 
      who did not receive ENBD were included in Group 2. The baseline clinical 
      characteristics were similar in both groups. There were no significant 
      differences in post-endoscopic retrograde cholangiopancreatography (ERCP)-related 
      complications when Groups 1 and 2 were compared. Seventy-seven patients underwent 
      EPBD, and 41 received an ENBD tube (G1a) and 36 did not (G2a). Seventy-three 
      patients underwent EST, and 34 patients received an ENBD tube (G1b) and 39 did 
      not (G2b). The remaining 68 patients underwent neither EPBD nor EST; of these 
      patients, 38 received an ENBD tube (G1c) and 30 did not (G2c). For each of the 
      three pairs of subgroups (G1a vs G2a, G1b vs G2b, G1c vs G2c), there were no 
      significant differences detected in the PHD or the time to normalization of CRP, 
      TB and ALT. In the EPBD group, the incidence of post-ERCP pancreatitis, 
      hyperamylasemia and overall patient complications was significantly higher for 
      G2a (post-ERCP pancreatitis: 6/36 vs 0/41, P=0.0217; hyperamylasemia: 11/36 vs 
      4/41, P=0.0215; overall patient complications: 18/36 vs 7/41, P=0.0029). 
      CONCLUSION: After successful CBD stone clearance, ENBD is only beneficial when an 
      EPBD procedure has been performed.
FAU - Xu, Xiao-Dan
AU  - Xu XD
AD  - Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of 
      Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 
      215500, Jiangsu Province, China.
FAU - Dai, Jian-Jun
AU  - Dai JJ
AD  - Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of 
      Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 
      215500, Jiangsu Province, China.
FAU - Qian, Jian-Qing
AU  - Qian JQ
AD  - Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of 
      Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 
      215500, Jiangsu Province, China.
FAU - Wang, Wei-Jun
AU  - Wang WJ
AD  - Xiao-Dan Xu, Jian-Jun Dai, Jian-Qing Qian, Wei-Jun Wang, Department of 
      Gastroenterology, Changshu Affiliated Hospital of Suzhou University, Changshu 
      215500, Jiangsu Province, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - World J Gastroenterol
JT  - World journal of gastroenterology
JID - 100883448
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Catheters
MH  - China
MH  - Cholangiopancreatography, Endoscopic Retrograde/adverse effects/*methods
MH  - Choledocholithiasis/blood/diagnosis/*surgery
MH  - Dilatation
MH  - Drainage/adverse effects/instrumentation/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pancreatitis/blood/diagnosis/etiology/*prevention & control
MH  - Patient Selection
MH  - Prospective Studies
MH  - Risk Factors
MH  - Sphincterotomy, Endoscopic
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC4342922
OTO - NOTNLM
OT  - Endoscopic nasobiliary drainage
OT  - Endoscopic papillary balloon dilatation
OT  - Hyperamylasemia
OT  - Post-endoscopic retrograde cholangiopancreatography pancreatitis
EDAT- 2015/03/06 06:00
MHDA- 2015/09/29 06:00
PMCR- 2015/02/28
CRDT- 2015/03/06 06:00
PHST- 2014/08/02 00:00 [received]
PHST- 2014/09/23 00:00 [revised]
PHST- 2014/12/01 00:00 [accepted]
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2015/09/29 06:00 [medline]
PHST- 2015/02/28 00:00 [pmc-release]
AID - 10.3748/wjg.v21.i8.2443 [doi]
PST - ppublish
SO  - World J Gastroenterol. 2015 Feb 28;21(8):2443-9. doi: 10.3748/wjg.v21.i8.2443.