PMID- 25741530
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2333-2719 (Print)
IS  - 2333-3286 (Electronic)
IS  - 2333-3286 (Linking)
VI  - 1
IP  - 1
DP  - 2013 Sep
TI  - Interaction of HLA-DRB1*1501 and TNF-Alpha in a Population-based Case-control 
      Study of Multiple Sclerosis.
PG  - 10-17
AB  - This study was conducted to determine whether single nucleotide polymorphisms 
      (SNPs) in nine genes (human leukocyte antigen (HLA), T cell receptor beta (TCA 
      receptor beta), tumor necrosis factor alpha (TNF alpha), tumor necrosis factor beta (TNF beta), 
      apolipoprotein E (APOE), interleukin 7 receptor alpha chain (IL7RA) interleukin 2 
      receptor alpha chain (IL2RA) myelin basic protein (MBP) and vitamin D receptor 
      (VDR)) associated with multiple sclerosis (MS) could be replicated in a 
      population-based sample, and to determine if these associations are modified by 
      presence of HLA DRB1*1501. DNA was available from 722 individuals (223 with MS 
      and 499 controls) who participated in a population-based case-control study. 
      Cases and controls were matched on ancestry, age, gender and geographic area. HLA 
      DRB1*1501 risk allele (T) was confirmed in this population using a genotypic 
      test, controlling for multiple comparisons. Examining the effect of each SNP in 
      the presence or absence of the HLA DRB1*1501 risk allele identified significant 
      associations with TNF alpha -1031 (rs1799964) among those without the HLA risk 
      allele. No additional interactions were significant in a cases-only analysis. Our 
      results indicate that an interaction between SNPs in TNF alpha and HLA DRB1*1501 may 
      influence the risk of developing MS.
FAU - Williamson, Dhelia M
AU  - Williamson DM
AD  - Division of Reproductive Health, Centers for Disease Control and Prevention, 
      Atlanta, Georgia, 30333, United States.
FAU - Marrie, Ruth Ann
AU  - Marrie RA
AD  - Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, 
      Canada R3A 1R9.
FAU - Ashley-Koch, Allison
AU  - Ashley-Koch A
AD  - Center for Human Genetics, Duke University Medical Center, Durham, North 
      Carolina, 27710, United States.
FAU - Satten, Glen A
AU  - Satten GA
AD  - Division of Reproductive Health, Centers for Disease Control and Prevention, 
      Atlanta, Georgia, 30333, United States.
LA  - eng
GR  - CC999999/Intramural CDC HHS/United States
PT  - Journal Article
PL  - United States
TA  - Immunol Infect Dis
JT  - Immunology and infectious diseases
JID - 101651362
PMC - PMC4328031
MID - NIHMS655953
OTO - NOTNLM
OT  - A-DRB1*1501
OT  - Case-Control Study
OT  - Genetic Susceptibility
OT  - Gene-Gene Interaction
OT  - Multiple Sclerosis
OT  - Tumor Necrosis Factor-Alpha
EDAT- 2013/09/01 00:00
MHDA- 2013/09/01 00:01
PMCR- 2015/03/02
CRDT- 2015/03/06 06:00
PHST- 2015/03/06 06:00 [entrez]
PHST- 2013/09/01 00:00 [pubmed]
PHST- 2013/09/01 00:01 [medline]
PHST- 2015/03/02 00:00 [pmc-release]
AID - 10.13189/iid.2013.010102 [doi]
PST - ppublish
SO  - Immunol Infect Dis. 2013 Sep;1(1):10-17. doi: 10.13189/iid.2013.010102.