PMID- 25742056
OWN - NLM
STAT- MEDLINE
DCOM- 20160511
LR  - 20181113
IS  - 1552-9924 (Electronic)
IS  - 0091-6765 (Print)
IS  - 0091-6765 (Linking)
VI  - 123
IP  - 7
DP  - 2015 Jul
TI  - Prenatal and Postnatal Exposure to Persistent Organic Pollutants and Infant 
      Growth: A Pooled Analysis of Seven European Birth Cohorts.
PG  - 730-6
LID - 10.1289/ehp.1308005 [doi]
AB  - BACKGROUND: Infant exposure to persistent organic pollutants (POPs) may 
      contribute to obesity. However, many studies so far have been small, focused on 
      transplacental exposure, used an inappropriate measure to assess postnatal 
      exposure through breastfeeding if any, or did not discern between prenatal and 
      postnatal effects. OBJECTIVES: We investigated prenatal and postnatal exposure to 
      POPs and infant growth (a predictor of obesity). METHODS: We pooled data from 
      seven European birth cohorts with biomarker concentrations of polychlorinated 
      biphenyl 153 (PCB-153) (n = 2,487), and p,p'-dichlorodiphenyldichloroethylene 
      (p,p'-DDE) (n = 1,864), estimating prenatal and postnatal POPs exposure using a 
      validated pharmacokinetic model. Growth was change in weight-for-age z-score 
      between birth and 24 months. Per compound, multilevel models were fitted with 
      either POPs total exposure from conception to 24 months or prenatal or postnatal 
      exposure. RESULTS: We found a significant increase in growth associated with 
      p,p'-DDE, seemingly due to prenatal exposure (per interquartile increase in 
      exposure, adjusted beta = 0.12; 95% CI: 0.03, 0.22). Due to heterogeneity across 
      cohorts, this estimate cannot be considered precise, but does indicate that an 
      association with infant growth is present on average. In contrast, a significant 
      decrease in growth was associated with postnatal PCB-153 exposure (beta = -0.10; 95% 
      CI: -0.19, -0.01). CONCLUSION: To our knowledge, this is the largest study to 
      date of POPs exposure and infant growth, and it contains state-of-the-art 
      exposure modeling. Prenatal p,p'-DDE was associated with increased infant growth, 
      and postnatal PCB-153 with decreased growth at European exposure levels.
FAU - Iszatt, Nina
AU  - Iszatt N
AD  - Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
FAU - Stigum, Hein
AU  - Stigum H
FAU - Verner, Marc-Andre
AU  - Verner MA
FAU - White, Richard A
AU  - White RA
FAU - Govarts, Eva
AU  - Govarts E
FAU - Murinova, Lubica Palkovicova
AU  - Murinova LP
FAU - Schoeters, Greet
AU  - Schoeters G
FAU - Trnovec, Tomas
AU  - Trnovec T
FAU - Legler, Juliette
AU  - Legler J
FAU - Pele, Fabienne
AU  - Pele F
FAU - Botton, Jeremie
AU  - Botton J
FAU - Chevrier, Cecile
AU  - Chevrier C
FAU - Wittsiepe, Jurgen
AU  - Wittsiepe J
FAU - Ranft, Ulrich
AU  - Ranft U
FAU - Vandentorren, Stephanie
AU  - Vandentorren S
FAU - Kasper-Sonnenberg, Monika
AU  - Kasper-Sonnenberg M
FAU - Klumper, Claudia
AU  - Klumper C
FAU - Weisglas-Kuperus, Nynke
AU  - Weisglas-Kuperus N
FAU - Polder, Anuschka
AU  - Polder A
FAU - Eggesbo, Merete
AU  - Eggesbo M
CN  - OBELIX
LA  - eng
GR  - R01 CA096525/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150306
PL  - United States
TA  - Environ Health Perspect
JT  - Environmental health perspectives
JID - 0330411
RN  - 0 (Environmental Pollutants)
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Body Height/drug effects
MH  - Body Weight/drug effects
MH  - Child Development/*drug effects
MH  - Child, Preschool
MH  - Dichlorodiphenyl Dichloroethylene/blood/*toxicity
MH  - Environmental Pollutants/*toxicity
MH  - Europe
MH  - Female
MH  - Growth/*drug effects
MH  - Humans
MH  - Infant
MH  - Male
MH  - Maternal Exposure/adverse effects
MH  - Maternal-Fetal Exchange
MH  - Polychlorinated Biphenyls/blood/*toxicity
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
PMC - PMC4492262
COIS- The authors declare they have no actual or potential competing financial 
      interests.
EDAT- 2015/03/06 06:00
MHDA- 2016/05/12 06:00
PMCR- 2015/07/01
CRDT- 2015/03/06 06:00
PHST- 2013/12/13 00:00 [received]
PHST- 2015/03/03 00:00 [accepted]
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2016/05/12 06:00 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - ehp.1308005 [pii]
AID - 10.1289/ehp.1308005 [doi]
PST - ppublish
SO  - Environ Health Perspect. 2015 Jul;123(7):730-6. doi: 10.1289/ehp.1308005. Epub 
      2015 Mar 6.