PMID- 25742273
OWN - NLM
STAT- MEDLINE
DCOM- 20150914
LR  - 20181202
IS  - 1678-8060 (Electronic)
IS  - 0074-0276 (Print)
IS  - 0074-0276 (Linking)
VI  - 110
IP  - 1
DP  - 2015 Feb
TI  - The use of halloysite clay and carboxyl-functionalised multi-walled carbon 
      nanotubes for recombinant LipL32 antigen delivery enhanced the IgG response.
PG  - 134-7
LID - S0074-02762015000100134 [pii]
LID - 10.1590/0074-02760140276 [doi]
AB  - We studied the feasibility of using halloysite clay nanotubes (HNTs) and 
      carboxyl-functionalised multi-walled carbon nanotubes (COOH-MWCNTs) as antigen 
      carriers to improve immune responses against a recombinant LipL32 protein 
      (rLipL32). Immunisation using the HNTs or COOH-MWCNTs significantly increased the 
      rLipL32-specific IgG antibody titres (p < 0.05) of Golden Syrian hamsters. None 
      of the vaccines tested conferred protection against a challenge using a virulent 
      Leptospira interrogans strain. These results demonstrated that nanotubes can be 
      used as antigen carriers for delivery in hosts and the induction of a humoral 
      immune response against purified leptospiral antigens used in subunit vaccine 
      preparations.
FAU - Hartwig, Daiane D
AU  - Hartwig DD
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Bacelo, Katia L
AU  - Bacelo KL
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Oliveira, Thais L
AU  - Oliveira TL
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Schuch, Rodrigo
AU  - Schuch R
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Seixas, Fabiana K
AU  - Seixas FK
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Collares, Tiago
AU  - Collares T
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Rodrigues, Oscar
AU  - Rodrigues O
AD  - Departamento de Quimica, Universidade Federal de Santa Maria, Santa Maria, RS, 
      Brasil.
FAU - Hartleben, Claudia P
AU  - Hartleben CP
AD  - Centro de Desenvolvimento Tecnologico.
FAU - Dellagostin, Odir A
AU  - Dellagostin OA
AD  - Centro de Desenvolvimento Tecnologico.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150123
PL  - Brazil
TA  - Mem Inst Oswaldo Cruz
JT  - Memorias do Instituto Oswaldo Cruz
JID - 7502619
RN  - 0 (Aluminum Silicates)
RN  - 0 (Antigens)
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Bacterial Outer Membrane Proteins)
RN  - 0 (Bacterial Vaccines)
RN  - 0 (Immunoglobulin G)
RN  - 0 (LipL32 protein, Leptospira)
RN  - 0 (Lipoproteins)
RN  - 0 (Nanotubes, Carbon)
RN  - 0 (Recombinant Proteins)
RN  - 142M471B3J (Carbon Dioxide)
RN  - 14485-07-5 (carboxyl radical)
RN  - T1FAD4SS2M (Clay)
SB  - IM
MH  - Aluminum Silicates/*immunology
MH  - Animals
MH  - Antigens/administration & dosage
MH  - Antigens, Bacterial/administration & dosage/immunology
MH  - Bacterial Outer Membrane Proteins/*immunology
MH  - Bacterial Vaccines/*immunology
MH  - Carbon Dioxide/immunology
MH  - Clay
MH  - Cricetinae
MH  - Feasibility Studies
MH  - Immunity, Humoral/immunology
MH  - Immunoglobulin G/*analysis
MH  - Leptospira interrogans/classification/*immunology
MH  - Lipoproteins/*immunology
MH  - Mesocricetus
MH  - *Nanotubes, Carbon
MH  - Recombinant Proteins/administration & dosage/immunology
PMC - PMC4371227
EDAT- 2015/03/06 06:00
MHDA- 2015/09/15 06:00
PMCR- 2015/02/01
CRDT- 2015/03/06 06:00
PHST- 2014/08/01 00:00 [received]
PHST- 2014/12/08 00:00 [accepted]
PHST- 2015/03/06 06:00 [entrez]
PHST- 2015/03/06 06:00 [pubmed]
PHST- 2015/09/15 06:00 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - S0074-02762015000100134 [pii]
AID - 10.1590/0074-02760140276 [doi]
PST - ppublish
SO  - Mem Inst Oswaldo Cruz. 2015 Feb;110(1):134-7. doi: 10.1590/0074-02760140276. Epub 
      2015 Jan 23.