PMID- 25743837
OWN - NLM
STAT- MEDLINE
DCOM- 20151208
LR  - 20220331
IS  - 2476-762X (Electronic)
IS  - 1513-7368 (Linking)
VI  - 16
IP  - 4
DP  - 2015
TI  - The Health Examinees (HEXA) study: rationale, study design and baseline 
      characteristics.
PG  - 1591-7
AB  - BACKGROUND: Korea has experienced rapid economic development in a very short 
      period of time. A mixture of traditional and modern risk factors coexists and the 
      rapid change in non-genetic factors interacts with genetic constituents. With 
      consideration of these unique aspects of Korean society, a large-scale genomic 
      cohort study-the Health Examinees (HEXA) Study-has been conducted to investigate 
      epidemiologic characteristics, genomic features, and gene-environment 
      interactions of major chronic diseases including cancer in the Korean population. 
      MATERIALS AND METHODS: Following a standardized study protocol, the subjects were 
      prospectively recruited from 38 health examination centers and training hospitals 
      throughout the country. An interview- based questionnaire survey was conducted to 
      collect information on socio-demographic characteristics, medical history, 
      medication usage, family history, lifestyle factors, diet, physical activity, and 
      reproductive factors for women. Various biological specimens (i.e., plasma, 
      serum, buffy coat, blood cells, genomic DNA, and urine) were collected for 
      biorepository according to the standardized protocol. Skilled medical staff also 
      performed physical examinations. RESULTS: Between 2004 and 2013, a total of 
      167,169 subjects aged 40-69 years were recruited for the HEXA study. Participants 
      are being followed up utilizing active and passive methods. The first wave of 
      active follow-up began in 2012 and it will be continued until 2015. The principal 
      purpose of passive follow-up is based on data linkages with the National Death 
      Certificate, the National Cancer Registry, and the National Health Insurance 
      Claim data. CONCLUSIONS: The HEXA study will render an opportunity to investigate 
      biomarkers of early health index and the chronological changes associated with 
      chronic diseases.
FAU - Health Examinees Study Group
AU  - Health Examinees Study Group
AD  - Details of the study group members are provided in the Acknowledgments. E-mail : 
      dhkang@snu.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Thailand
TA  - Asian Pac J Cancer Prev
JT  - Asian Pacific journal of cancer prevention : APJCP
JID - 101130625
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Diet
MH  - *Epidemiologic Research Design
MH  - Female
MH  - Follow-Up Studies
MH  - *Gene-Environment Interaction
MH  - *Genomics
MH  - Humans
MH  - Incidence
MH  - *Life Style
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/diagnosis/*epidemiology/genetics
MH  - Prospective Studies
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
MH  - Surveys and Questionnaires
EDAT- 2015/03/07 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/03/07 06:00
PHST- 2015/03/07 06:00 [entrez]
PHST- 2015/03/07 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
AID - 10.7314/apjcp.2015.16.4.1591 [doi]
PST - ppublish
SO  - Asian Pac J Cancer Prev. 2015;16(4):1591-7. doi: 10.7314/apjcp.2015.16.4.1591.