PMID- 2574428
OWN - NLM
STAT- MEDLINE
DCOM- 19900125
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 105
IP  - 3
DP  - 1989 Nov 6
TI  - The N-methyl-D-aspartate (NMDA) receptor antagonist, dextrorphan, prevents the 
      neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA) in rats.
PG  - 300-6
AB  - Using the systemically active, non-competitive N-methyl-D-aspartate (NMDA) 
      receptor antagonist dextrorphan, we explored the role of the NMDA 
      receptor-calcium channel complex in the toxic mechanism of action of 
      3,4-methylenedioxymethamphetamine (MDMA). Rats were treated with MDMA, 
      dextrorphan, or the combination of MDMA and increasing doses of dextrorphan, and 
      then killed 10 days later for the assay of serotonin and dopamine in the 
      striatum, hippocampus, and cortex. Dextrorphan totally prevented the 
      serotonin-depleting effects of MDMA in the straitum, with a lessened but still 
      significant blockade noted in the hippocampus and cortex. These findings may 
      provide a clue to the molecular events underlying MDMA-induced neurotoxicity.
FAU - Finnegan, K T
AU  - Finnegan KT
AD  - Institute For Medical Research, San Jose, CA 95128.
FAU - Skratt, J J
AU  - Skratt JJ
FAU - Irwin, I
AU  - Irwin I
FAU - Langston, J W
AU  - Langston JW
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amphetamines)
RN  - 0 (Morphinans)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Receptors, Neurotransmitter)
RN  - 04B7QNO9WS (Dextrorphan)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/administration & dosage/analogs & 
      derivatives/*antagonists & inhibitors/toxicity
MH  - Amphetamines/*antagonists & inhibitors
MH  - Animals
MH  - Brain/drug effects/metabolism
MH  - Calcium/metabolism
MH  - Dextrorphan/*pharmacology
MH  - Male
MH  - Morphinans/*pharmacology
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Receptors, Neurotransmitter/*antagonists & inhibitors/metabolism
EDAT- 1989/11/06 00:00
MHDA- 1989/11/06 00:01
CRDT- 1989/11/06 00:00
PHST- 1989/11/06 00:00 [pubmed]
PHST- 1989/11/06 00:01 [medline]
PHST- 1989/11/06 00:00 [entrez]
AID - 0304-3940(89)90637-X [pii]
AID - 10.1016/0304-3940(89)90637-x [doi]
PST - ppublish
SO  - Neurosci Lett. 1989 Nov 6;105(3):300-6. doi: 10.1016/0304-3940(89)90637-x.